Effects of carmustine and lomustine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adducts in rat glial tumor cells

Carmustine and lomustine are nitrosourea antitumor chemotherapeutic agents which were used to determine whether or not they could affect arylamine N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adducts in rat glial tumor cell line (C6 glioma). The NAT activity was measured by high prefor...

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Veröffentlicht in:	Neurochemical research 2000-06, Vol.25 (6), p.845-851
1. Verfasser:	HUNG, C. F
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminofluorene Animals Antineoplastic agents Arylamine N-Acetyltransferase - metabolism Biological and medical sciences Brain Neoplasms - enzymology Brain Neoplasms - metabolism carmustine Carmustine - pharmacology Chemotherapy DNA Adducts - metabolism Fluorenes - metabolism Glioma - metabolism Kinetics lomustine Lomustine - pharmacology Medical sciences Pharmacology. Drug treatments Rats Tumor Cells, Cultured
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