Spherocyte shape transformation and release of tubular nanovesicles in human erythrocytes

We have studied dodecylmaltoside-induced echinocyte–spheroechincyte–spherocyte shape transformation and membrane vesiculation using transmission electron microscopy (TEM) on freeze-fracture replicas. It is indicated that spherical erythrocyte shape at higher dodecylmaltoside concentration is formed...

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Veröffentlicht in:	Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2004-05, Vol.62 (2), p.159-161
Hauptverfasser:	Iglič, Aleš, Veranič, Peter, Jezernik, Kristijan, Fošnarič, Miha, Kamin, Boris, Hägerstrand, Henry, Kralj-Iglič, Veronika
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Shape - drug effects Cell Surface Extensions - drug effects Detergents - pharmacology Dodecylmaltoside Erythrocyte membrane Erythrocyte Membrane - drug effects Erythrocyte shape Erythrocytes - drug effects Erythrocytes - metabolism Erythrocytes - ultrastructure Freeze Fracturing Glucosides - pharmacology Humans Membrane shear energy Microscopy, Electron, Transmission Nanovesicles Particle Size Spherocytes - drug effects Spherocytes - pathology
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Beschreibung
Zusammenfassung:	We have studied dodecylmaltoside-induced echinocyte–spheroechincyte–spherocyte shape transformation and membrane vesiculation using transmission electron microscopy (TEM) on freeze-fracture replicas. It is indicated that spherical erythrocyte shape at higher dodecylmaltoside concentration is formed due to loss of membrane in the process where small, mostly tubular nanovesicles are released predominantly from the top of echinocyte and spheroechinocyte spicules.
ISSN:	1567-5394 1878-562X
DOI:	10.1016/j.bioelechem.2003.07.002