Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection
Minocycline is currently under development as a neuroprotective agent in many different brain diseases. In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this r...
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| Veröffentlicht in: | Experimental neurology 2004-04, Vol.186 (2), p.248-251 |
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| container_title | Experimental neurology |
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| creator | Fagan, Susan C. Edwards, David J. Borlongan, Cesar V. Xu, Lin Arora, Ankur Feuerstein, Giora Hess, David C. |
| description | Minocycline is currently under development as a neuroprotective agent in many different brain diseases. In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this route of administration and makes a case for intravenous dosing in experimental animals, particularly for acute neuroprotection, to optimize delivery to the brain and facilitate translation to human studies. |
| doi_str_mv | 10.1016/j.expneurol.2003.12.006 |
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In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this route of administration and makes a case for intravenous dosing in experimental animals, particularly for acute neuroprotection, to optimize delivery to the brain and facilitate translation to human studies.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2003.12.006</identifier><identifier>PMID: 15026261</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood–brain barrier ; Brain - drug effects ; Brain - metabolism ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Chromatography, High Pressure Liquid - methods ; Dose ; Drug Administration Routes ; Drug Administration Schedule ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Hydrogen-Ion Concentration ; Infectious diseases ; Intraperitoneal ; Male ; Medical sciences ; Minocycline ; Minocycline - administration & dosage ; Minocycline - blood ; Minocycline - cerebrospinal fluid ; Minocycline - pharmacokinetics ; Neuroprotection ; Neuroprotective Agents - administration & dosage ; Neuroprotective Agents - blood ; Neuroprotective Agents - cerebrospinal fluid ; Neuroprotective Agents - pharmacokinetics ; Pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Temperature ; Time Factors ; Vertebrates: nervous system and sense organs ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this route of administration and makes a case for intravenous dosing in experimental animals, particularly for acute neuroprotection, to optimize delivery to the brain and facilitate translation to human studies.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood–brain barrier</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dose</subject><subject>Drug Administration Routes</subject><subject>Drug Administration Schedule</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infectious diseases</subject><subject>Intraperitoneal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Minocycline</subject><subject>Minocycline - administration & dosage</subject><subject>Minocycline - blood</subject><subject>Minocycline - cerebrospinal fluid</subject><subject>Minocycline - pharmacokinetics</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Neuroprotective Agents - blood</subject><subject>Neuroprotective Agents - cerebrospinal fluid</subject><subject>Neuroprotective Agents - pharmacokinetics</subject><subject>Pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZfCXwBf6G3TseN8casqCkiVeoGz5dgT1SvHDrZTsf8eh10BN04zh-edefUQ8p5BxYC1N4cKfy4e1xhcxQHqivEKoH1BdgwG2HNRw0uyA2BiL_q-vSSvUzoAwCB494pcsgZ4y1u2I-ZxyXZWjhp09hnjkYaJztYHfdTOeqQ50PyEdIzK-o_UzouzWmUbPJ1CpE_rrDxNeTUW0xZVes1IfzdbYsioN_QNuZiUS_j2PK_I9_tP3-6-7B8eP3-9u33Ya9HWuTSFsR-R49AJqIUxaHRt1DhqxZumZYb1ndGAbOxACQ5T3dcM-96UvQMQ9RW5Pt0tr3-smLKcbdLonPIY1iQ71olmGLoCdidQx5BSxEkusViIR8lAboLlQf4RLDfBknFZBJfku_OLdZzR_M2djRbgwxlQSSs3ReW1Tf9wzcB4vx26PXFYhDxbjDJpi16jsbFYkybY_5b5BZILn5Q</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Fagan, Susan C.</creator><creator>Edwards, David J.</creator><creator>Borlongan, Cesar V.</creator><creator>Xu, Lin</creator><creator>Arora, Ankur</creator><creator>Feuerstein, Giora</creator><creator>Hess, David C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection</title><author>Fagan, Susan C. ; Edwards, David J. ; Borlongan, Cesar V. ; Xu, Lin ; Arora, Ankur ; Feuerstein, Giora ; Hess, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-480b8be2e974034ddedc3dabbca25561d187dc0e1b70a420f3831e88d42070043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood–brain barrier</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dose</topic><topic>Drug Administration Routes</topic><topic>Drug Administration Schedule</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infectious diseases</topic><topic>Intraperitoneal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Minocycline</topic><topic>Minocycline - administration & dosage</topic><topic>Minocycline - blood</topic><topic>Minocycline - cerebrospinal fluid</topic><topic>Minocycline - pharmacokinetics</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Neuroprotective Agents - blood</topic><topic>Neuroprotective Agents - cerebrospinal fluid</topic><topic>Neuroprotective Agents - pharmacokinetics</topic><topic>Pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fagan, Susan C.</creatorcontrib><creatorcontrib>Edwards, David J.</creatorcontrib><creatorcontrib>Borlongan, Cesar V.</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Arora, Ankur</creatorcontrib><creatorcontrib>Feuerstein, Giora</creatorcontrib><creatorcontrib>Hess, David C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fagan, Susan C.</au><au>Edwards, David J.</au><au>Borlongan, Cesar V.</au><au>Xu, Lin</au><au>Arora, Ankur</au><au>Feuerstein, Giora</au><au>Hess, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>186</volume><issue>2</issue><spage>248</spage><epage>251</epage><pages>248-251</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Minocycline is currently under development as a neuroprotective agent in many different brain diseases. In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this route of administration and makes a case for intravenous dosing in experimental animals, particularly for acute neuroprotection, to optimize delivery to the brain and facilitate translation to human studies.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>15026261</pmid><doi>10.1016/j.expneurol.2003.12.006</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood–brain barrier Brain - drug effects Brain - metabolism Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Chromatography, High Pressure Liquid - methods Dose Drug Administration Routes Drug Administration Schedule Fundamental and applied biological sciences. Psychology Human viral diseases Hydrogen-Ion Concentration Infectious diseases Intraperitoneal Male Medical sciences Minocycline Minocycline - administration & dosage Minocycline - blood Minocycline - cerebrospinal fluid Minocycline - pharmacokinetics Neuroprotection Neuroprotective Agents - administration & dosage Neuroprotective Agents - blood Neuroprotective Agents - cerebrospinal fluid Neuroprotective Agents - pharmacokinetics Pharmacokinetics Rats Rats, Sprague-Dawley Temperature Time Factors Vertebrates: nervous system and sense organs Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection |
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