Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group

Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the clinical use of this risk-management strategy. Thus, we estimated the degree of breast cancer risk reduction after surgery in women wh...

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Veröffentlicht in:	Journal of clinical oncology 2004-03, Vol.22 (6), p.1055-1062
Hauptverfasser:	REBBECK, Timothy R, FRIEBEL, Tara, DALY, Mary B, OLOPADE, Olufunmilayo I, WEBER, Barbara L, LYNCH, Henry T, NEUHAUSEN, Susan L, VAN'T VEER, Laura, GARBER, Judy E, EVANS, Gareth R, NAROD, Steven A, ISAACS, Claudine, MATLOFF, Ellen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Breast Neoplasms - epidemiology Breast Neoplasms - prevention & control Case-Control Studies Europe - epidemiology Female Genes, BRCA1 Genes, BRCA2 Genetic Predisposition to Disease Gynecology. Andrology. Obstetrics Heterozygote Humans Mammary gland diseases Mastectomy Medical sciences Middle Aged Mutation North America - epidemiology Proportional Hazards Models Prospective Studies Retrospective Studies Risk Assessment Treatment Outcome Tumors
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