Glucose-Regulated Protein 94/Glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production In Vivo

Glucose-regulated protein 94 (GRP94/gp96), the endoplasmic reticulum heat shock protein 90 paralog, elicits both innate and adaptive immune responses. Regarding the former, GRP94/gp96 stimulates APC cytokine expression and dendritic cell maturation. The adaptive component of GRP94/gp96 function refl...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-04, Vol.172 (7), p.4195-4203
Hauptverfasser:	Baker-LePain, Julie C, Sarzotti, Marcella, Nicchitta, Christopher V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - administration & dosage Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - physiology Bystander Effect - immunology CD11b Antigen - biosynthesis CD11c Antigen - biosynthesis CD3 Complex - biosynthesis CD4 Antigens - biosynthesis CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cytokines - biosynthesis Cytotoxicity, Immunologic Female Fibroblasts - immunology Fibroblasts - metabolism Fibroblasts - transplantation HSP70 Heat-Shock Proteins - administration & dosage HSP70 Heat-Shock Proteins - metabolism HSP70 Heat-Shock Proteins - physiology Injections, Subcutaneous Interferon-gamma - biosynthesis Interferon-gamma - metabolism Killer Cells, Natural - immunology Lymphocyte Activation - immunology Lymphoid Tissue - immunology Lymphoid Tissue - metabolism Membrane Proteins - administration & dosage Membrane Proteins - metabolism Membrane Proteins - physiology Mice Mice, Inbred BALB C Phagocytes - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th1 Cells - immunology Th1 Cells - metabolism Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism
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