Reaction Trajectory of Pyrophosphoryl Transfer Catalyzed by 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) catalyzes the Mg 2+-dependent pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The reaction follows a bi-bi mechanism with ATP as the first substrate and AMP and HP pyrophosphate (HPPP) as the two products. HPPK is...

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Veröffentlicht in:	Structure 2004-03, Vol.12 (3), p.467-475
Hauptverfasser:	Blaszczyk, Jaroslaw, Shi, Genbin, Li, Yue, Yan, Honggao, Ji, Xinhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - metabolism BASIC BIOLOGICAL SCIENCES CHEMICAL REACTION KINETICS Crystallography, X-Ray Diphosphotransferases - chemistry Diphosphotransferases - metabolism ENZYME ACTIVITY Escherichia coli - enzymology Kinetics Models, Molecular NATIONAL SYNCHROTRON LIGHT SOURCE PHOSPHOTRANSFERASES Protein Structure, Tertiary Thermodynamics
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