GABAB receptor stimulation decreases amphetamine-induced behavior and neuropeptide gene expression in the striatum

The purpose of this study was to investigate whether GABA(B) receptor activation blocks acute amphetamine-induced behavioral activity, dopamine release, and neuropeptide mRNA expression in the striatum. Systemic administration of R-(+)-baclofen (1.25 mg/kg, i.p.) did not alter total distance travele...

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Veröffentlicht in:	Brain research 2004-04, Vol.1004 (1-2), p.18-28
Hauptverfasser:	WENXIA ZHOU, MAILLOUX, Adam W, JUNG, Bruce J, EDMUNDS, Hayward S, MCGINTY, Jacqueline F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - pharmacology Animals Baclofen - pharmacology Biological and medical sciences Corpus Striatum - drug effects Corpus Striatum - metabolism GABA-B Receptor Agonists Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Male Medical sciences Motor Activity - drug effects Motor Activity - physiology Neuropeptides - biosynthesis Neuropeptides - genetics Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, GABA-B - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics
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