The Nck family of adapter proteins: Regulators of actin cytoskeleton
SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in regulating tyrosine kinase signalling. They serve to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. Initially, it was not clear why cells from nematodes to verteb...
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| Veröffentlicht in: | Cellular Signalling 2002-09, Vol.14 (9), p.723-731 |
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| container_title | Cellular Signalling |
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| creator | Buday, László Wunderlich, Livius Tamás, Peter |
| description | SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in regulating tyrosine kinase signalling. They serve to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. Initially, it was not clear why cells from nematodes to vertebrates contain redundant and closely related SH2/SH3 adapters, such as Grb2, Crk and Nck. Recent evidence suggests that their biological roles are clearly different, whereas, for example, Grb2 connects activated receptor tyrosine kinases to Sos and Ras, leading to cell proliferation. The proteins of Nck family are implicated in organisation of actin cytoskeleton, cell movement or axon guidance in flies. In this review, the author attempts to summarise signalling pathways in which Nck plays a critical role. |
| doi_str_mv | 10.1016/S0898-6568(02)00027-X |
| format | Article |
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In this review, the author attempts to summarise signalling pathways in which Nck plays a critical role.</description><subject>Actin cytoskeleton</subject><subject>Actin Cytoskeleton - metabolism</subject><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Integrins - metabolism</subject><subject>Lymphocyte Activation</subject><subject>Models, Biological</subject><subject>Nck</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Oncogene Proteins - chemistry</subject><subject>Oncogene Proteins - physiology</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins p21(ras) - metabolism</subject><subject>Rho proteins</subject><subject>SH2/SH3 domains</subject><subject>Signal Transduction</subject><subject>src Homology Domains</subject><subject>T-Lymphocytes - immunology</subject><issn>0898-6568</issn><issn>1873-3913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlOwzAURS0EoqXwCaCsECwCHmLHYYNQGaUKJChSd5bjPINphhI7SP170gFWd_GOnu49CB0TfEEwEZdvWGYyFlzIM0zPMcY0jWc7aEhkymKWEbaLhv_IAB14_4Ux4VjQfTQgFLOEcTZEt9NPiJ7NPLK6cuUyamykC70I0EaLtgngan8VvcJHV-rQtH59N8HVkVmGxs-hhNDUh2jP6tLD0TZH6P3-bjp-jCcvD0_jm0lsGOEhTrk1wIlgNjGZtDijkMtMC6u1ECaxhQSS5jLJreE850WaWW15jrHWkFEu2Aidbv721b478EFVzhsoS11D03mVkjRhjCY9eLIFu7yCQi1aV-l2qf5298D1BoC-7o-DVnnjoDZQuBZMUEXjFMFqZVqtTauVRoWpWptWM_YLPq9v_A</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Buday, László</creator><creator>Wunderlich, Livius</creator><creator>Tamás, Peter</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>The Nck family of adapter proteins: Regulators of actin cytoskeleton</title><author>Buday, László ; Wunderlich, Livius ; Tamás, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-75fce5163f4c98f092eb89a6faa66c4fd8e17b84bfc55b5d79faf5b00aae92563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Actin cytoskeleton</topic><topic>Actin Cytoskeleton - metabolism</topic><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Axons - physiology</topic><topic>Integrins - metabolism</topic><topic>Lymphocyte Activation</topic><topic>Models, Biological</topic><topic>Nck</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Oncogene Proteins - chemistry</topic><topic>Oncogene Proteins - physiology</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins p21(ras) - metabolism</topic><topic>Rho proteins</topic><topic>SH2/SH3 domains</topic><topic>Signal Transduction</topic><topic>src Homology Domains</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buday, László</creatorcontrib><creatorcontrib>Wunderlich, Livius</creatorcontrib><creatorcontrib>Tamás, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular Signalling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buday, László</au><au>Wunderlich, Livius</au><au>Tamás, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Nck family of adapter proteins: Regulators of actin cytoskeleton</atitle><jtitle>Cellular Signalling</jtitle><addtitle>Cell Signal</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>14</volume><issue>9</issue><spage>723</spage><epage>731</epage><pages>723-731</pages><issn>0898-6568</issn><eissn>1873-3913</eissn><abstract>SH2/SH3 domain-containing adapter proteins, such as the Nck family, play a major role in regulating tyrosine kinase signalling. 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| ispartof | Cellular Signalling, 2002-09, Vol.14 (9), p.723-731 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Actin cytoskeleton Actin Cytoskeleton - metabolism Adaptor Proteins, Signal Transducing Animals Axons - physiology Integrins - metabolism Lymphocyte Activation Models, Biological Nck Nerve Tissue Proteins - physiology Oncogene Proteins - chemistry Oncogene Proteins - physiology Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins p21(ras) - metabolism Rho proteins SH2/SH3 domains Signal Transduction src Homology Domains T-Lymphocytes - immunology |
| title | The Nck family of adapter proteins: Regulators of actin cytoskeleton |
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