PET Studies of the Effects of Aerobic Exercise on Human Striatal Dopamine Release
In vivo microdialysis studies have shown that exercise increases the concentration of dopamine (DA) in the striatum of the rat brain. It has also been shown that PET with [11C]raclopride can be used to assess changes in brain DA induced by drugs and by performance tasks such as playing a video game....
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2000-08, Vol.41 (8), p.1352-1356 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Wang, Gene-Jack Volkow, Nora D Fowler, Joanna S Franceschi, Dinko Logan, Jean Pappas, Naomi R Wong, Christopher T Netusil, Noelwah |
| description | In vivo microdialysis studies have shown that exercise increases the concentration of dopamine (DA) in the striatum of the rat brain. It has also been shown that PET with [11C]raclopride can be used to assess changes in brain DA induced by drugs and by performance tasks such as playing a video game. The purpose of this study was to evaluate the effects of exercise (treadmill running) on striatal DA release in the human brain.
Twelve healthy volunteers (5 women, 7 men; mean age, 32 +/- 5 y; age range, 25-40 y) with a history of regular exercise received 2 PET scans with [11C]raclopride on 2 separate days, 1 at baseline and 1 at 5-10 min after running on a treadmill for 30 min. The speed and inclination of the treadmill were increased gradually to reach a maximal speed of 9.7 km/h (6 mph) and a maximal inclination of 10degrees. Data were acquired on a Siemens HR+ scanner in 3-dimensional mode for 60 min. Heart rates and electrocardiograms were monitored. DA D2 receptor availability was measured using the ratio of the distribution volume in the putamen to that in the cerebellum, which is a function of the number of available binding sites/dissociation constant.
The subjects ran at an average speed of 8.7 +/- 0.5 km/h (5.4 +/- 0.3 mph) and at an inclination of 3.3degrees +/- 2degrees. The maximum effort of running was maintained for 10-15 min. The heart rates of the subjects were increased by 143% +/- 47%. DA D2 receptor availability in the putamen after treadmill running (4.22 +/- 0.34) was no different from that of baseline (4.17 +/- 0.29; P < 0.6).
No significant changes in synaptic DA concentration were detected, although the subjects exercised vigorously for 30 min. |
| format | Article |
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Twelve healthy volunteers (5 women, 7 men; mean age, 32 +/- 5 y; age range, 25-40 y) with a history of regular exercise received 2 PET scans with [11C]raclopride on 2 separate days, 1 at baseline and 1 at 5-10 min after running on a treadmill for 30 min. The speed and inclination of the treadmill were increased gradually to reach a maximal speed of 9.7 km/h (6 mph) and a maximal inclination of 10degrees. Data were acquired on a Siemens HR+ scanner in 3-dimensional mode for 60 min. Heart rates and electrocardiograms were monitored. DA D2 receptor availability was measured using the ratio of the distribution volume in the putamen to that in the cerebellum, which is a function of the number of available binding sites/dissociation constant.
The subjects ran at an average speed of 8.7 +/- 0.5 km/h (5.4 +/- 0.3 mph) and at an inclination of 3.3degrees +/- 2degrees. The maximum effort of running was maintained for 10-15 min. The heart rates of the subjects were increased by 143% +/- 47%. DA D2 receptor availability in the putamen after treadmill running (4.22 +/- 0.34) was no different from that of baseline (4.17 +/- 0.29; P < 0.6).
No significant changes in synaptic DA concentration were detected, although the subjects exercised vigorously for 30 min.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 10945526</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Adult ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Carbon Radioisotopes - pharmacokinetics ; Central nervous system ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - physiology ; Dopamine - metabolism ; Exercise - physiology ; Exercise Test ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Jogging ; Male ; Medical sciences ; Nervous system ; Physical Exertion - physiology ; Raclopride - pharmacokinetics ; Radionuclide investigations ; Rats ; Receptors, Dopamine D2 - analysis ; Receptors, Dopamine D2 - metabolism ; Reference Values ; Tomography, Emission-Computed ; Vertebrates: nervous system and sense organs</subject><ispartof>The Journal of nuclear medicine (1978), 2000-08, Vol.41 (8), p.1352-1356</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Society of Nuclear Medicine Aug 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1465731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10945526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Gene-Jack</creatorcontrib><creatorcontrib>Volkow, Nora D</creatorcontrib><creatorcontrib>Fowler, Joanna S</creatorcontrib><creatorcontrib>Franceschi, Dinko</creatorcontrib><creatorcontrib>Logan, Jean</creatorcontrib><creatorcontrib>Pappas, Naomi R</creatorcontrib><creatorcontrib>Wong, Christopher T</creatorcontrib><creatorcontrib>Netusil, Noelwah</creatorcontrib><title>PET Studies of the Effects of Aerobic Exercise on Human Striatal Dopamine Release</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>In vivo microdialysis studies have shown that exercise increases the concentration of dopamine (DA) in the striatum of the rat brain. It has also been shown that PET with [11C]raclopride can be used to assess changes in brain DA induced by drugs and by performance tasks such as playing a video game. The purpose of this study was to evaluate the effects of exercise (treadmill running) on striatal DA release in the human brain.
Twelve healthy volunteers (5 women, 7 men; mean age, 32 +/- 5 y; age range, 25-40 y) with a history of regular exercise received 2 PET scans with [11C]raclopride on 2 separate days, 1 at baseline and 1 at 5-10 min after running on a treadmill for 30 min. The speed and inclination of the treadmill were increased gradually to reach a maximal speed of 9.7 km/h (6 mph) and a maximal inclination of 10degrees. Data were acquired on a Siemens HR+ scanner in 3-dimensional mode for 60 min. Heart rates and electrocardiograms were monitored. DA D2 receptor availability was measured using the ratio of the distribution volume in the putamen to that in the cerebellum, which is a function of the number of available binding sites/dissociation constant.
The subjects ran at an average speed of 8.7 +/- 0.5 km/h (5.4 +/- 0.3 mph) and at an inclination of 3.3degrees +/- 2degrees. The maximum effort of running was maintained for 10-15 min. The heart rates of the subjects were increased by 143% +/- 47%. DA D2 receptor availability in the putamen after treadmill running (4.22 +/- 0.34) was no different from that of baseline (4.17 +/- 0.29; P < 0.6).
No significant changes in synaptic DA concentration were detected, although the subjects exercised vigorously for 30 min.</description><subject>Adult</subject><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes - pharmacokinetics</subject><subject>Central nervous system</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - physiology</subject><subject>Dopamine - metabolism</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Jogging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Physical Exertion - physiology</subject><subject>Raclopride - pharmacokinetics</subject><subject>Radionuclide investigations</subject><subject>Rats</subject><subject>Receptors, Dopamine D2 - analysis</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Reference Values</subject><subject>Tomography, Emission-Computed</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0F1LwzAUBuAiipvTvyBBRK8KzWfbyzGrEwZ-zeuSpicuo01n0qL-e6ObCN54FU548nLy7kVjzCmPuRDpfjROsMAx5wkfRUfer5MkEVmWHUYjnOSMcyLG0cN9sURP_VAb8KjTqF8BKrQG1X-PU3BdZRQq3sEp4wF1Fs2HVtrwxhnZywZddRvZGgvoERqQHo6jAy0bDye7cxI9XxfL2Txe3N3czqaLeEWJ6GMdllFQ5SLljFPBdJ0QUok6D_eiJhQISEWkrImiWOaEVZoKTpiqcpmKWtBJdLHN3bjudQDfl63xCppGWugGX6Y4ZRSL_yHOMOc8pwGe_YHrbnA2fKIkOA9xOSEBne7QULVQlxtnWuk-yp9KAzjfAemVbLSTNjT365jgKcWBXW7Zyrys3oyD0g4qFOi-Qte2ZbjMSkw5oZ_1QIsl</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Wang, Gene-Jack</creator><creator>Volkow, Nora D</creator><creator>Fowler, Joanna S</creator><creator>Franceschi, Dinko</creator><creator>Logan, Jean</creator><creator>Pappas, Naomi R</creator><creator>Wong, Christopher T</creator><creator>Netusil, Noelwah</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>PET Studies of the Effects of Aerobic Exercise on Human Striatal Dopamine Release</title><author>Wang, Gene-Jack ; Volkow, Nora D ; Fowler, Joanna S ; Franceschi, Dinko ; Logan, Jean ; Pappas, Naomi R ; Wong, Christopher T ; Netusil, Noelwah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h326t-f006ceb967545364fd022b6d90066d23e2eac2aad2c31a924bf36524cb9a76d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes - pharmacokinetics</topic><topic>Central nervous system</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - physiology</topic><topic>Dopamine - metabolism</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Jogging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Physical Exertion - physiology</topic><topic>Raclopride - pharmacokinetics</topic><topic>Radionuclide investigations</topic><topic>Rats</topic><topic>Receptors, Dopamine D2 - analysis</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Reference Values</topic><topic>Tomography, Emission-Computed</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Gene-Jack</creatorcontrib><creatorcontrib>Volkow, Nora D</creatorcontrib><creatorcontrib>Fowler, Joanna S</creatorcontrib><creatorcontrib>Franceschi, Dinko</creatorcontrib><creatorcontrib>Logan, Jean</creatorcontrib><creatorcontrib>Pappas, Naomi R</creatorcontrib><creatorcontrib>Wong, Christopher T</creatorcontrib><creatorcontrib>Netusil, Noelwah</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Gene-Jack</au><au>Volkow, Nora D</au><au>Fowler, Joanna S</au><au>Franceschi, Dinko</au><au>Logan, Jean</au><au>Pappas, Naomi R</au><au>Wong, Christopher T</au><au>Netusil, Noelwah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PET Studies of the Effects of Aerobic Exercise on Human Striatal Dopamine Release</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>41</volume><issue>8</issue><spage>1352</spage><epage>1356</epage><pages>1352-1356</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>In vivo microdialysis studies have shown that exercise increases the concentration of dopamine (DA) in the striatum of the rat brain. It has also been shown that PET with [11C]raclopride can be used to assess changes in brain DA induced by drugs and by performance tasks such as playing a video game. The purpose of this study was to evaluate the effects of exercise (treadmill running) on striatal DA release in the human brain.
Twelve healthy volunteers (5 women, 7 men; mean age, 32 +/- 5 y; age range, 25-40 y) with a history of regular exercise received 2 PET scans with [11C]raclopride on 2 separate days, 1 at baseline and 1 at 5-10 min after running on a treadmill for 30 min. The speed and inclination of the treadmill were increased gradually to reach a maximal speed of 9.7 km/h (6 mph) and a maximal inclination of 10degrees. Data were acquired on a Siemens HR+ scanner in 3-dimensional mode for 60 min. Heart rates and electrocardiograms were monitored. DA D2 receptor availability was measured using the ratio of the distribution volume in the putamen to that in the cerebellum, which is a function of the number of available binding sites/dissociation constant.
The subjects ran at an average speed of 8.7 +/- 0.5 km/h (5.4 +/- 0.3 mph) and at an inclination of 3.3degrees +/- 2degrees. The maximum effort of running was maintained for 10-15 min. The heart rates of the subjects were increased by 143% +/- 47%. DA D2 receptor availability in the putamen after treadmill running (4.22 +/- 0.34) was no different from that of baseline (4.17 +/- 0.29; P < 0.6).
No significant changes in synaptic DA concentration were detected, although the subjects exercised vigorously for 30 min.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>10945526</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Animals Biochemistry and metabolism Biological and medical sciences Carbon Radioisotopes - pharmacokinetics Central nervous system Corpus Striatum - diagnostic imaging Corpus Striatum - physiology Dopamine - metabolism Exercise - physiology Exercise Test Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Jogging Male Medical sciences Nervous system Physical Exertion - physiology Raclopride - pharmacokinetics Radionuclide investigations Rats Receptors, Dopamine D2 - analysis Receptors, Dopamine D2 - metabolism Reference Values Tomography, Emission-Computed Vertebrates: nervous system and sense organs |
| title | PET Studies of the Effects of Aerobic Exercise on Human Striatal Dopamine Release |
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