T‐cell expansions in patients with multiple myeloma have a phenotype of cytotoxic T cells
The presence of T‐cell clones in peripheral blood has been previously shown to be associated with a survival advantage in patients with multiple myeloma and suggests that the expanded T‐cell populations may be involved in an anti‐tumour response. We studied the T‐cell receptor (TCR) repertoire of 38...
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| Veröffentlicht in: | British journal of haematology 2000-07, Vol.110 (1), p.203-209 |
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| creator | Raitakari, Maria Brown, Ross D. Sze, Daniel Yuen, Edna Barrow, Lisa Nelson, Margaret Pope, Belinda Esdale, Warren Gibson, John Joshua, Douglas E. |
| description | The presence of T‐cell clones in peripheral blood has been previously shown to be associated with a survival advantage in patients with multiple myeloma and suggests that the expanded T‐cell populations may be involved in an anti‐tumour response. We studied the T‐cell receptor (TCR) repertoire of 38 patients with myeloma to identify and characterize the expanded T‐cell populations by flow cytometry. T‐cell expansions were found in 79% of the patients. The expansions occurred randomly among the 21 variable regions of the TCR β chain (Vβ) studied, representing 62% of the V‐β repertoire, and were stable during an 18‐month follow‐up. The phenotype of the expanded V‐β populations was predominantly CD8+, CD57+, CD28− and perforin+, which differed significantly from the other non‐expanded Vβ populations. The expression of the apoptosis markers Fas (CD95) and bcl‐2 were similar between the expanded and non‐expanded Vβ populations. In conclusion, expanded T‐cell populations were frequent in patients with myeloma, they remained unchanged during follow‐up and had phenotypic characteristics of cytotoxic T cells. These data add further support to the concept that the T‐cell expansions may have an immunoregulatory role in myeloma. |
| doi_str_mv | 10.1046/j.1365-2141.2000.02131.x |
| format | Article |
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These data add further support to the concept that the T‐cell expansions may have an immunoregulatory role in myeloma.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2000.02131.x</identifier><identifier>PMID: 10930999</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Analysis of Variance ; Biological and medical sciences ; CD57 Antigens - analysis ; CD8 Antigens - analysis ; Female ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; immunophenotype ; Immunophenotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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We studied the T‐cell receptor (TCR) repertoire of 38 patients with myeloma to identify and characterize the expanded T‐cell populations by flow cytometry. T‐cell expansions were found in 79% of the patients. The expansions occurred randomly among the 21 variable regions of the TCR β chain (Vβ) studied, representing 62% of the V‐β repertoire, and were stable during an 18‐month follow‐up. The phenotype of the expanded V‐β populations was predominantly CD8+, CD57+, CD28− and perforin+, which differed significantly from the other non‐expanded Vβ populations. The expression of the apoptosis markers Fas (CD95) and bcl‐2 were similar between the expanded and non‐expanded Vβ populations. In conclusion, expanded T‐cell populations were frequent in patients with myeloma, they remained unchanged during follow‐up and had phenotypic characteristics of cytotoxic T cells. These data add further support to the concept that the T‐cell expansions may have an immunoregulatory role in myeloma.</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>CD57 Antigens - analysis</subject><subject>CD8 Antigens - analysis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>immunophenotype</subject><subject>Immunophenotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - analysis</subject><subject>Middle Aged</subject><subject>monoclonal antibody</subject><subject>Multiple Myeloma - immunology</subject><subject>myeloma</subject><subject>Perforin</subject><subject>Pore Forming Cytotoxic Proteins</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Reference Values</subject><subject>T cell</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>TCR</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL-O00AQh1cIxIWDV0BbIDqbmf0TewsKOMEd6CSaUFGsNuuxspHtNV7nLu54BJ6RJzmbREBJNSPN95sZfYxxhBxBrd_sc5RrnQlUmAsAyEGgxPz4iK3-DB6z1TwpsjlQXrBnKe0BUILGp-wCwUgwxqzYt82vHz89NQ2nY--6FGKXeOh478ZA3Zj4fRh3vD00Y-gb4u1ETWwd37k74o73O-riOPXEY839NMYxHoPnG75sTM_Zk9o1iV6c6yX7-vHD5uomu_1y_enq3W3mlVKYbQVqoUibSq-NlttCSFNhsaVS-qIEcAgOCllLr2tVr0mArKD2WmuBVemcvGSvT3v7IX4_UBptG9LygesoHpItsFDCCDOD5Qn0Q0xpoNr2Q2jdMFkEu4i1e7v4s4s_u4i1v8Xa4xx9eb5x2LZU_RM8mZyBV2fAJe-aenCdD-kvp0pA0DP29oTdh4am_75v33--WTr5ABAnk_U</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Raitakari, Maria</creator><creator>Brown, Ross D.</creator><creator>Sze, Daniel</creator><creator>Yuen, Edna</creator><creator>Barrow, Lisa</creator><creator>Nelson, Margaret</creator><creator>Pope, Belinda</creator><creator>Esdale, Warren</creator><creator>Gibson, John</creator><creator>Joshua, Douglas E.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200007</creationdate><title>T‐cell expansions in patients with multiple myeloma have a phenotype of cytotoxic T cells</title><author>Raitakari, Maria ; Brown, Ross D. ; Sze, Daniel ; Yuen, Edna ; Barrow, Lisa ; Nelson, Margaret ; Pope, Belinda ; Esdale, Warren ; Gibson, John ; Joshua, Douglas E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4441-b21524e59d56953b7239d17be83c7800a10a073f3c5f4f6e203d0fc55521d8aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>CD57 Antigens - analysis</topic><topic>CD8 Antigens - analysis</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>immunophenotype</topic><topic>Immunophenotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - analysis</topic><topic>Middle Aged</topic><topic>monoclonal antibody</topic><topic>Multiple Myeloma - immunology</topic><topic>myeloma</topic><topic>Perforin</topic><topic>Pore Forming Cytotoxic Proteins</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - immunology</topic><topic>Reference Values</topic><topic>T cell</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>TCR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raitakari, Maria</creatorcontrib><creatorcontrib>Brown, Ross D.</creatorcontrib><creatorcontrib>Sze, Daniel</creatorcontrib><creatorcontrib>Yuen, Edna</creatorcontrib><creatorcontrib>Barrow, Lisa</creatorcontrib><creatorcontrib>Nelson, Margaret</creatorcontrib><creatorcontrib>Pope, Belinda</creatorcontrib><creatorcontrib>Esdale, Warren</creatorcontrib><creatorcontrib>Gibson, John</creatorcontrib><creatorcontrib>Joshua, Douglas E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raitakari, Maria</au><au>Brown, Ross D.</au><au>Sze, Daniel</au><au>Yuen, Edna</au><au>Barrow, Lisa</au><au>Nelson, Margaret</au><au>Pope, Belinda</au><au>Esdale, Warren</au><au>Gibson, John</au><au>Joshua, Douglas E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T‐cell expansions in patients with multiple myeloma have a phenotype of cytotoxic T cells</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2000-07</date><risdate>2000</risdate><volume>110</volume><issue>1</issue><spage>203</spage><epage>209</epage><pages>203-209</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>The presence of T‐cell clones in peripheral blood has been previously shown to be associated with a survival advantage in patients with multiple myeloma and suggests that the expanded T‐cell populations may be involved in an anti‐tumour response. We studied the T‐cell receptor (TCR) repertoire of 38 patients with myeloma to identify and characterize the expanded T‐cell populations by flow cytometry. T‐cell expansions were found in 79% of the patients. The expansions occurred randomly among the 21 variable regions of the TCR β chain (Vβ) studied, representing 62% of the V‐β repertoire, and were stable during an 18‐month follow‐up. The phenotype of the expanded V‐β populations was predominantly CD8+, CD57+, CD28− and perforin+, which differed significantly from the other non‐expanded Vβ populations. The expression of the apoptosis markers Fas (CD95) and bcl‐2 were similar between the expanded and non‐expanded Vβ populations. In conclusion, expanded T‐cell populations were frequent in patients with myeloma, they remained unchanged during follow‐up and had phenotypic characteristics of cytotoxic T cells. These data add further support to the concept that the T‐cell expansions may have an immunoregulatory role in myeloma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10930999</pmid><doi>10.1046/j.1365-2141.2000.02131.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Analysis of Variance Biological and medical sciences CD57 Antigens - analysis CD8 Antigens - analysis Female Flow Cytometry Hematologic and hematopoietic diseases Humans immunophenotype Immunophenotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Linear Models Male Medical sciences Membrane Glycoproteins - analysis Middle Aged monoclonal antibody Multiple Myeloma - immunology myeloma Perforin Pore Forming Cytotoxic Proteins Receptors, Antigen, T-Cell, alpha-beta - immunology Reference Values T cell T-Lymphocytes, Cytotoxic - immunology TCR |
| title | T‐cell expansions in patients with multiple myeloma have a phenotype of cytotoxic T cells |
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