Mechanisms of action of melanin-concentrating hormone in the teleost fish erythrophoroma cell line (GEM-81)

Melanin-concentrating hormone (MCH) evokes an increase of GEM-81 cell proliferation. This action of 10 −6 M MCH was inhibited in the presence of the following blockers: U-73122 (phospholipase C), Ro-31-8220 (PKC) or KN-93 (Ca 2+/calmodulin-dependent kinase). The more selective PKC inhibitors, HBDDE...

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Veröffentlicht in:	General and comparative endocrinology 2004-04, Vol.136 (2), p.270-275
Hauptverfasser:	Isoldi, Mauro César, Benabou, Mara Helena de Pina, Schumacher, Robert Ivan, Góis, Carolina Costa, Scarparo, Ana Cristina, Rebouças, Nancy Amaral, Visconti, Maria Aparecida
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzylamines - pharmacology Cell Division - drug effects Cell signaling Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Enzyme Inhibitors - pharmacology Estrenes - pharmacology Fish Diseases - pathology GEM-81 Goldfish Hypothalamic Hormones - antagonists & inhibitors Hypothalamic Hormones - pharmacology Indoles - pharmacology Melanin-concentrating hormone Melanins - antagonists & inhibitors Melanins - pharmacology Pituitary Hormones - antagonists & inhibitors Pituitary Hormones - pharmacology Protein kinase A Protein kinase C Protein Kinase C - antagonists & inhibitors Pyrrolidinones - pharmacology Skin Neoplasms - pathology Skin Neoplasms - veterinary Sulfonamides - pharmacology Teleost fish Teleostei Tumor Cells, Cultured Type C Phospholipases - antagonists & inhibitors
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