Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4

Ca 2+ /calmodulin-dependent protein kinase IV (Camk4; also known as CaMKIV), a multifunctional serine/threonine protein kinase with limited tissue distribution, has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells 1 , 2 , 3 , 4 , 5 , 6 . In the mouse testis,...

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Veröffentlicht in:	Nature genetics 2000-08, Vol.25 (4), p.448-452
Hauptverfasser:	Wu, Joy Y., Ribar, Thomas J., Cummings, David E., Burton, Kimberly A., McKnight, G. Stanley, Means, Anthony R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals basic nuclear proteins Biological and medical sciences Biomedical and Life Sciences Biomedicine Calcium-Calmodulin-Dependent Protein Kinase Type 4 Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calmodulin Camk4 gene Cancer Research Cell differentiation, maturation, development, hematopoiesis Cell physiology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Gene Function Genetic aspects Human Genetics Infertility Kinases letter Lymphocytes Male Males Mammals Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Molecular and cellular biology Molecular Sequence Data Morphology Nuclear Proteins - metabolism Phosphorylation Physiological aspects protamine-2 Protamines - genetics Protamines - metabolism Protein kinases Proteins Retention Sperm Sperm Count Spermatogenesis Spermatogenesis - physiology Spermatozoa Spermatozoa - cytology Spermatozoa - enzymology Spermatozoa - metabolism Stem cells Testes Testis - growth & development Testis - metabolism
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