The mammary gland iodide transporter is expressed during lactation and in breast cancer
The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable success in the detection and treatment of thyroid cancer. Here we show that a specialized form of the sodium...
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| Veröffentlicht in: | Nature medicine 2000-08, Vol.6 (8), p.871-878 |
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| creator | Tazebay, Uygar H. Wapnir, Irene L. Levy, Orlie Dohan, Orsolya Zuckier, Lionel S. Hua Zhao, Qing Fu Deng, Hou Amenta, Peter S. Fineberg, Susan Pestell, Richard G. Carrasco, Nancy |
| description | The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable success in the detection and treatment of thyroid cancer. Here we show that a specialized form of the sodium/iodide symporter in the mammary gland mediates active iodide transport in healthy lactating (but not in nonlactating) mammary gland and in mammary tumors. In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing
Ras
or
Neu
oncogenes actively accumulate iodide by this symporter
in vivo
. Moreover, more than 80% of the human breast cancer samples we analyzed by immunohistochemistry expressed the symporter, compared with none of the normal (nonlactating) samples from reductive mammoplasties. These results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer. |
| doi_str_mv | 10.1038/78630 |
| format | Article |
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Ras
or
Neu
oncogenes actively accumulate iodide by this symporter
in vivo
. Moreover, more than 80% of the human breast cancer samples we analyzed by immunohistochemistry expressed the symporter, compared with none of the normal (nonlactating) samples from reductive mammoplasties. These results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/78630</identifier><identifier>PMID: 10932223</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Amino Acid Sequence ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Breast - metabolism ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - metabolism ; Breast Neoplasms - radiotherapy ; Cancer Research ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Female ; Gene Expression - drug effects ; Hormones - pharmacology ; Humans ; Infectious Diseases ; iodide transport ; Iodides ; Iodides - metabolism ; Iodine Radioisotopes - therapeutic use ; Lactation - metabolism ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - metabolism ; Mammary Neoplasms, Experimental - metabolism ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Metabolic Diseases ; Mice ; Mice, Transgenic ; Molecular Medicine ; neu gene ; Neurosciences ; Ovariectomy ; Pregnancy ; Rats ; Sodium ; Symporters ; Thyroid</subject><ispartof>Nature medicine, 2000-08, Vol.6 (8), p.871-878</ispartof><rights>Nature America Inc. 2000</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-9c0930754ffc7902fb446b157a31c0112576fc09444e514f12bcd6e8aadb8b843</citedby><cites>FETCH-LOGICAL-c604t-9c0930754ffc7902fb446b157a31c0112576fc09444e514f12bcd6e8aadb8b843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/78630$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/78630$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10932223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tazebay, Uygar H.</creatorcontrib><creatorcontrib>Wapnir, Irene L.</creatorcontrib><creatorcontrib>Levy, Orlie</creatorcontrib><creatorcontrib>Dohan, Orsolya</creatorcontrib><creatorcontrib>Zuckier, Lionel S.</creatorcontrib><creatorcontrib>Hua Zhao, Qing</creatorcontrib><creatorcontrib>Fu Deng, Hou</creatorcontrib><creatorcontrib>Amenta, Peter S.</creatorcontrib><creatorcontrib>Fineberg, Susan</creatorcontrib><creatorcontrib>Pestell, Richard G.</creatorcontrib><creatorcontrib>Carrasco, Nancy</creatorcontrib><title>The mammary gland iodide transporter is expressed during lactation and in breast cancer</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable success in the detection and treatment of thyroid cancer. Here we show that a specialized form of the sodium/iodide symporter in the mammary gland mediates active iodide transport in healthy lactating (but not in nonlactating) mammary gland and in mammary tumors. In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing
Ras
or
Neu
oncogenes actively accumulate iodide by this symporter
in vivo
. Moreover, more than 80% of the human breast cancer samples we analyzed by immunohistochemistry expressed the symporter, compared with none of the normal (nonlactating) samples from reductive mammoplasties. These results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Cancer Research</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Female</subject><subject>Gene Expression - drug effects</subject><subject>Hormones - pharmacology</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>iodide transport</subject><subject>Iodides</subject><subject>Iodides - metabolism</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Lactation - metabolism</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Molecular Medicine</subject><subject>neu 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lactation and in breast cancer</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>6</volume><issue>8</issue><spage>871</spage><epage>878</epage><pages>871-878</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable success in the detection and treatment of thyroid cancer. Here we show that a specialized form of the sodium/iodide symporter in the mammary gland mediates active iodide transport in healthy lactating (but not in nonlactating) mammary gland and in mammary tumors. In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing
Ras
or
Neu
oncogenes actively accumulate iodide by this symporter
in vivo
. Moreover, more than 80% of the human breast cancer samples we analyzed by immunohistochemistry expressed the symporter, compared with none of the normal (nonlactating) samples from reductive mammoplasties. These results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>10932223</pmid><doi>10.1038/78630</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2000-08, Vol.6 (8), p.871-878 |
| issn | 1078-8956 1546-170X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Amino Acid Sequence Animals Biomedical and Life Sciences Biomedicine Breast - metabolism Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Breast Neoplasms - radiotherapy Cancer Research Carrier Proteins - genetics Carrier Proteins - metabolism Female Gene Expression - drug effects Hormones - pharmacology Humans Infectious Diseases iodide transport Iodides Iodides - metabolism Iodine Radioisotopes - therapeutic use Lactation - metabolism Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Mammary Neoplasms, Experimental - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Metabolic Diseases Mice Mice, Transgenic Molecular Medicine neu gene Neurosciences Ovariectomy Pregnancy Rats Sodium Symporters Thyroid |
| title | The mammary gland iodide transporter is expressed during lactation and in breast cancer |
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