Immunization with a DNA vaccine encoding the hepatitis-C-virus structural antigens elicits a specific immune response against the capsid and envelope proteins in rabbits and Macaca irus (crab-eating macaque monkeys)

In the present study, we evaluated the capability of the plasmid pIDKE2, encoding the HCV (hepatitis C virus) structural proteins Core, E1 and E2, to induce immune response against HCV antigens after injection into rabbits and Macaca irus (crab‐eating macaque). Animals were immunized intramuscularly...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2004-04, Vol.39 (2), p.249-255
Hauptverfasser:	Dueñas-Carrera, Santiago, Viña, Ariel, Martínez, Rafael, Alvarez-Lajonchere, Liz, Alvarez-Obregón, Julio César, Marante, Jeny, Pérez, Anna, Mosqueda, Omar, Martínez, Gillian, Morales, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibody response Antigens, Viral - administration & dosage Antigens, Viral - immunology Biological and medical sciences Biotechnology Capsid Proteins - immunology core envelope Female Fundamental and applied biological sciences. Psychology Gene Transfer Techniques Genetic Therapy - methods Hepatitis C - immunology Hepatitis C - prevention & control Hepatitis C Antibodies - immunology Hepatitis C virus HVR-1 Immunization - methods Immunotherapy - methods lymphoproliferation Macaca Macaca irus Male Rabbits Species Specificity Vaccination - methods Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Viral Envelope Proteins - metabolism
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