Mesp2 initiates somite segmentation through the Notch signalling pathway

The Notch-signalling pathway is important in establishing metameric pattern during somitogenesis. In mice, the lack of either of two molecules involved in the Notch-signalling pathway, Mesp2 or presenilin-1 (Ps1), results in contrasting phenotypes: caudalized versus rostralized vertebra. Here we ado...

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Veröffentlicht in:	Nature genetics 2000-08, Vol.25 (4), p.390-396
Hauptverfasser:	Takahashi, Yu, Koizumi, Ken-ichi, Takagi, Atsuya, Kitajima, Satoshi, Inoue, Tohru, Koseki, Haruhiko, Saga, Yumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Basic Helix-Loop-Helix Transcription Factors Biological and medical sciences Biomedical and Life Sciences Biomedicine Body Patterning - genetics Cancer Research Cell differentiation, maturation, development, hematopoiesis Cell physiology Cellular signal transduction Cloning D111 gene Embryo, Mammalian - metabolism Embryos Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Gene Function Genes Genetics Human Genetics Humans Ligands Male Membrane Proteins - genetics Membrane Proteins - physiology Mesp2 gene Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Molecular and cellular biology Mutation Presenilin-1 Ps-1 protein Receptors, Notch Segmentation (Morphology) Signal Transduction Somite Somites - physiology Transcription Factors - genetics Transcription Factors - physiology
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