A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding

A positron-emitter labeled radioligand for the glycine-binding site of the N-methyl- d-aspartate (NMDA) receptor, [ 11C]L-703,717, was examined for its ability to penetrate the brain in animals by simultaneous use with drugs having high-affinity separate binding sites on human serum albumin. [ 11C]L...

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