The role of regulated protein degradation in auxin response
Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Ar...
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| Veröffentlicht in: | Plant molecular biology 2002-06, Vol.49 (3-4), p.401-408 |
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| creator | Dharmasiri, Sunethra Estelle, Mark |
| description | Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCF(TIR1), a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. Further, recent biochemical experiments indicate that the Aux/IAA proteins bind SCF(TIR1) in an auxin-dependent manner. |
| doi_str_mv | 10.1023/a:1015203013208 |
| format | Article |
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The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCF(TIR1), a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. Further, recent biochemical experiments indicate that the Aux/IAA proteins bind SCF(TIR1) in an auxin-dependent manner.</description><identifier>ISSN: 0167-4412</identifier><identifier>EISSN: 1573-5028</identifier><identifier>DOI: 10.1023/a:1015203013208</identifier><identifier>PMID: 12036263</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Arabidopsis ; Arabidopsis - drug effects ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Biodegradation ; Cysteine Endopeptidases - metabolism ; Gene expression ; Gene Expression Regulation, Plant - drug effects ; Indoleacetic Acids - metabolism ; Indoleacetic Acids - pharmacology ; Models, Biological ; Multienzyme Complexes - metabolism ; Plant Proteins - metabolism ; Plants - drug effects ; Plants - genetics ; Plants - metabolism ; Proteasome Endopeptidase Complex ; Protein Binding ; Proteins ; Signal Transduction ; Transcription Factors - metabolism ; Ubiquitin - metabolism</subject><ispartof>Plant molecular biology, 2002-06, Vol.49 (3-4), p.401-408</ispartof><rights>Kluwer Academic Publishers 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-988b1407d9364a75e87dd0d1a68e2e7bc5c729e3b1ffcde0415afcc738ca08943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12036263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dharmasiri, Sunethra</creatorcontrib><creatorcontrib>Estelle, Mark</creatorcontrib><title>The role of regulated protein degradation in auxin response</title><title>Plant molecular biology</title><addtitle>Plant Mol Biol</addtitle><description>Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCF(TIR1), a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. 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| subjects | Arabidopsis Arabidopsis - drug effects Arabidopsis - genetics Arabidopsis - metabolism Biodegradation Cysteine Endopeptidases - metabolism Gene expression Gene Expression Regulation, Plant - drug effects Indoleacetic Acids - metabolism Indoleacetic Acids - pharmacology Models, Biological Multienzyme Complexes - metabolism Plant Proteins - metabolism Plants - drug effects Plants - genetics Plants - metabolism Proteasome Endopeptidase Complex Protein Binding Proteins Signal Transduction Transcription Factors - metabolism Ubiquitin - metabolism |
| title | The role of regulated protein degradation in auxin response |
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