Crystal Structure and Immunoglobulin G Binding Properties of the Human Major Histocompatibility Complex-Related Fc Receptor

The neonatal Fc receptor (FcRn) performs two distinct but related functions:  transport of maternal immunoglobulin G (IgG) to pre- or neonatal mammals, thus providing passive immunity, and protection of IgG from normal serum protein catabolism. FcRn is related to class I MHC proteins but lacks a fun...

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Veröffentlicht in:	Biochemistry (Easton) 2000-08, Vol.39 (32), p.9698-9708
Hauptverfasser:	West, Anthony P, Bjorkman, Pamela J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Crystallography, X-Ray Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - metabolism Humans Immunoglobulin G - chemistry Immunoglobulin G - metabolism Models, Molecular Molecular Sequence Data Protein Binding Receptors, Fc - chemistry Receptors, Fc - metabolism Sequence Homology, Amino Acid Species Specificity Surface Properties
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