Stabilization of oligonucleotide–polyethylenimine complexes by freeze-drying: physicochemical and biological characterization

In the present study the lyophilization of oligodeoxynucleotide–polyethylenimine (ODN–PEI) complexes was investigated regarding the maintenance of physicochemical properties and influence on biological activity. To achieve this, we used PEI of different molecular weights, in the range of 800–0.8 kDa...

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Veröffentlicht in:	Journal of controlled release 2004-02, Vol.95 (1), p.119-131
Hauptverfasser:	Brus, Carola, Kleemann, Elke, Aigner, Achim, Czubayko, Frank, Kissel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Atomic force microscopy Biological and medical sciences Carbohydrates - chemistry Cell Line, Tumor Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical DNA - administration & dosage DNA - genetics Excipients Female Freeze Drying Gene Transfer Techniques General pharmacology Laser-Doppler Flowmetry Luciferases - genetics Lyophilization Medical sciences Mice Microscopy, Atomic Force Molecular Weight Oligonucleotides Oligonucleotides - administration & dosage Oligonucleotides - chemistry Ovarian Neoplasms - genetics Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmids - genetics Polyethyleneimine - chemistry Polyethylenimine Ribozymes RNA, Catalytic - genetics Transfection
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