p53 is a regulator of macrophage differentiation

While it is well accepted that p53 plays a role in apoptosis, less is known as to its involvement in cell differentiation. Here we show that wild-type p53 facilitates IL-6-dependent macrophage differentiation. Treatment of M1/2 cells expressing the temperature-sensitive p53 143 (Val to Ala) mutant,...

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Veröffentlicht in:	Cell death and differentiation 2004-04, Vol.11 (4), p.458-467
Hauptverfasser:	Matas, D, Milyavsky, M, Shats, I, Nissim, L, Goldfinger, N, Rotter, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Biochemistry Biomedical and Life Sciences Cell Biology Cell cycle Cell Cycle Analysis Cell death Cell Differentiation - drug effects Cell Differentiation - physiology Clone Cells Cloning Cytokines Gene Expression Regulation Interleukin-6 - pharmacology Life Sciences Macrophages - physiology Mice Mutation Myeloid Cells - physiology original-paper Proteins Stem Cells Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology
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