Fecal Glucocorticoid Metabolites as a Measure of Adrenal Activity in Dairy Cattle
The feasibility of monitoring acute adrenal activity in New Zealand dairy cattle by measuring fecal glucocorticoid metabolites was investigated. Fecal glucocorticoid measurement has potential as an indicator of adrenal activity and animal stress because sampling is relatively noninvasive, does not i...
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| Veröffentlicht in: | General and comparative endocrinology 2002-04, Vol.126 (2), p.229-241 |
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| container_title | General and comparative endocrinology |
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| creator | Morrow, Catherine J. Kolver, Eric S. Verkerk, Gwyneth A. Matthews, Lindsay R. |
| description | The feasibility of monitoring acute adrenal activity in New Zealand dairy cattle by measuring fecal glucocorticoid metabolites was investigated. Fecal glucocorticoid measurement has potential as an indicator of adrenal activity and animal stress because sampling is relatively noninvasive, does not interfere with the stress response itself, and permits on-farm monitoring. Fecal samples were collected from dairy cattle following ACTH challenge and exposure to stressors (novel environment, transport). Two immunoassays (11,17-dioxoandrostane enzymeimmunoassay and ICN corticosterone radioimmunoassay) were compared. Both assays detected increased immunoreactive fecal glucocorticoid metabolites following acute adrenal activity and the temporal relationship between plasma corticosteroids and fecal metabolite excretion was determined. The time to peak excretion was closely related to the transit time of digesta passing between the bile duct and the rectum and was affected by seasonal changes in feed intake and pasture digestibility. We conclude that measurement of glucocorticoid metabolites reliably indicates acute adrenal activity in dairy cattle and in combination with other physiological and behavioral measures has potential for monitoring health and welfare in dairy cattle. |
| doi_str_mv | 10.1006/gcen.2002.7797 |
| format | Article |
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We conclude that measurement of glucocorticoid metabolites reliably indicates acute adrenal activity in dairy cattle and in combination with other physiological and behavioral measures has potential for monitoring health and welfare in dairy cattle.</description><identifier>ISSN: 0016-6480</identifier><identifier>EISSN: 1095-6840</identifier><identifier>DOI: 10.1006/gcen.2002.7797</identifier><identifier>PMID: 12030779</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ACTH ; Adrenal Glands - physiology ; Adrenocorticotropic Hormone ; Androstanes - analysis ; Animals ; Cattle - physiology ; Corticosterone - analysis ; cortisol ; dairy cow ; Eating ; fecal metabolites ; Feces - chemistry ; Female ; Gastrointestinal Transit ; glucocorticoids ; Glucocorticoids - analysis ; Glucocorticoids - metabolism ; Immunoenzyme Techniques ; Lactation ; Pregnancy ; Radioimmunoassay ; Seasons ; stress</subject><ispartof>General and comparative endocrinology, 2002-04, Vol.126 (2), p.229-241</ispartof><rights>2002 Elsevier Science (USA)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-be96d80c9e3c240f13cdc287660ebe4f87d40531d09f523ea5da2a800854cc4c3</citedby><cites>FETCH-LOGICAL-c340t-be96d80c9e3c240f13cdc287660ebe4f87d40531d09f523ea5da2a800854cc4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001664800297797X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12030779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morrow, Catherine J.</creatorcontrib><creatorcontrib>Kolver, Eric S.</creatorcontrib><creatorcontrib>Verkerk, Gwyneth A.</creatorcontrib><creatorcontrib>Matthews, Lindsay R.</creatorcontrib><title>Fecal Glucocorticoid Metabolites as a Measure of Adrenal Activity in Dairy Cattle</title><title>General and comparative endocrinology</title><addtitle>Gen Comp Endocrinol</addtitle><description>The feasibility of monitoring acute adrenal activity in New Zealand dairy cattle by measuring fecal glucocorticoid metabolites was investigated. Fecal glucocorticoid measurement has potential as an indicator of adrenal activity and animal stress because sampling is relatively noninvasive, does not interfere with the stress response itself, and permits on-farm monitoring. Fecal samples were collected from dairy cattle following ACTH challenge and exposure to stressors (novel environment, transport). Two immunoassays (11,17-dioxoandrostane enzymeimmunoassay and ICN corticosterone radioimmunoassay) were compared. Both assays detected increased immunoreactive fecal glucocorticoid metabolites following acute adrenal activity and the temporal relationship between plasma corticosteroids and fecal metabolite excretion was determined. The time to peak excretion was closely related to the transit time of digesta passing between the bile duct and the rectum and was affected by seasonal changes in feed intake and pasture digestibility. We conclude that measurement of glucocorticoid metabolites reliably indicates acute adrenal activity in dairy cattle and in combination with other physiological and behavioral measures has potential for monitoring health and welfare in dairy cattle.</description><subject>ACTH</subject><subject>Adrenal Glands - physiology</subject><subject>Adrenocorticotropic Hormone</subject><subject>Androstanes - analysis</subject><subject>Animals</subject><subject>Cattle - physiology</subject><subject>Corticosterone - analysis</subject><subject>cortisol</subject><subject>dairy cow</subject><subject>Eating</subject><subject>fecal metabolites</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gastrointestinal Transit</subject><subject>glucocorticoids</subject><subject>Glucocorticoids - analysis</subject><subject>Glucocorticoids - metabolism</subject><subject>Immunoenzyme Techniques</subject><subject>Lactation</subject><subject>Pregnancy</subject><subject>Radioimmunoassay</subject><subject>Seasons</subject><subject>stress</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlavHmVP3rZONtmvY6lWBUUEPYd0MiuR7UaTrNB_b0oLnoTAQHjel5mHsUsOcw5Q3XwgDfMCoJjXdVsfsSmHtsyrRsIxmwLwKq9kAxN2FsInAJSi4qdswgsQkAJT9roi1H1234_o0Plo0VmTPVPUa9fbSCHT6aUPHUZPmeuyhfE0pMgCo_2xcZvZIbvV1m-zpY6xp3N20uk-0MVhztj76u5t-ZA_vdw_LhdPOQoJMV9TW5kGsCWBhYSOCzRYNHVVAa1Jdk1tZFqXG2i7shCkS6ML3QA0pUSUKGbset_75d33SCGqjQ1Ifa8HcmNQNa-FrLlI4HwPoncheOrUl7cb7beKg9pJVDuJaidR7SSmwNWheVxvyPzhB2sJaPYApft-LHkV0NKAZKwnjMo4-1_3L0zVgCM</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Morrow, Catherine J.</creator><creator>Kolver, Eric S.</creator><creator>Verkerk, Gwyneth A.</creator><creator>Matthews, Lindsay R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Fecal Glucocorticoid Metabolites as a Measure of Adrenal Activity in Dairy Cattle</title><author>Morrow, Catherine J. ; Kolver, Eric S. ; Verkerk, Gwyneth A. ; Matthews, Lindsay R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-be96d80c9e3c240f13cdc287660ebe4f87d40531d09f523ea5da2a800854cc4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>ACTH</topic><topic>Adrenal Glands - physiology</topic><topic>Adrenocorticotropic Hormone</topic><topic>Androstanes - analysis</topic><topic>Animals</topic><topic>Cattle - physiology</topic><topic>Corticosterone - analysis</topic><topic>cortisol</topic><topic>dairy cow</topic><topic>Eating</topic><topic>fecal metabolites</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Gastrointestinal Transit</topic><topic>glucocorticoids</topic><topic>Glucocorticoids - analysis</topic><topic>Glucocorticoids - metabolism</topic><topic>Immunoenzyme Techniques</topic><topic>Lactation</topic><topic>Pregnancy</topic><topic>Radioimmunoassay</topic><topic>Seasons</topic><topic>stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morrow, Catherine J.</creatorcontrib><creatorcontrib>Kolver, Eric S.</creatorcontrib><creatorcontrib>Verkerk, Gwyneth A.</creatorcontrib><creatorcontrib>Matthews, Lindsay R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morrow, Catherine J.</au><au>Kolver, Eric S.</au><au>Verkerk, Gwyneth A.</au><au>Matthews, Lindsay R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fecal Glucocorticoid Metabolites as a Measure of Adrenal Activity in Dairy Cattle</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>126</volume><issue>2</issue><spage>229</spage><epage>241</epage><pages>229-241</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>The feasibility of monitoring acute adrenal activity in New Zealand dairy cattle by measuring fecal glucocorticoid metabolites was investigated. Fecal glucocorticoid measurement has potential as an indicator of adrenal activity and animal stress because sampling is relatively noninvasive, does not interfere with the stress response itself, and permits on-farm monitoring. Fecal samples were collected from dairy cattle following ACTH challenge and exposure to stressors (novel environment, transport). Two immunoassays (11,17-dioxoandrostane enzymeimmunoassay and ICN corticosterone radioimmunoassay) were compared. Both assays detected increased immunoreactive fecal glucocorticoid metabolites following acute adrenal activity and the temporal relationship between plasma corticosteroids and fecal metabolite excretion was determined. The time to peak excretion was closely related to the transit time of digesta passing between the bile duct and the rectum and was affected by seasonal changes in feed intake and pasture digestibility. We conclude that measurement of glucocorticoid metabolites reliably indicates acute adrenal activity in dairy cattle and in combination with other physiological and behavioral measures has potential for monitoring health and welfare in dairy cattle.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12030779</pmid><doi>10.1006/gcen.2002.7797</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ACTH Adrenal Glands - physiology Adrenocorticotropic Hormone Androstanes - analysis Animals Cattle - physiology Corticosterone - analysis cortisol dairy cow Eating fecal metabolites Feces - chemistry Female Gastrointestinal Transit glucocorticoids Glucocorticoids - analysis Glucocorticoids - metabolism Immunoenzyme Techniques Lactation Pregnancy Radioimmunoassay Seasons stress |
| title | Fecal Glucocorticoid Metabolites as a Measure of Adrenal Activity in Dairy Cattle |
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