Transcriptional Regulation of IL-5 Gene by Nontransformed Human T Cells Through the Proximal Promoter Element

Objective IL-5 is strongly involved in the eosinophilic inflammation in bronchial asthma and atopic dermatitis. We have previously reported that IL-5 synthesis in atopic and nonatopic asthmatics is significantly enhanced compared to control subjects. T cell IL-5 synthesis is regulated through severa...

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Veröffentlicht in:	Internal Medicine 2000, Vol.39(8), pp.618-625
Hauptverfasser:	MORI, Akio, KAMINUMA, Osamu, OGAWA, Koji, OKUDAIRA, Hirokazu, AKIYAMA, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergic diseases allergy Asthma - genetics Asthma - immunology Base Sequence Biological and medical sciences bronchial asthma Case-Control Studies Concanavalin A - pharmacology DNA - chemistry DNA - genetics eosinophilic inflammation gene transcription Humans Immunopathology In Vitro Techniques Interleukin-5 - biosynthesis Interleukin-5 - genetics Lymphocyte Activation Medical sciences NF-AT Nucleic Acid Conformation Promoter Regions, Genetic Respiratory and ent allergic diseases T-Lymphocytes - immunology Transcription, Genetic Transfection
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