Sex differences in cocaine-induced behavioral responses, pharmacokinetics, and monoamine levels

Female rats display a more robust behavioral response to acute cocaine administration than do male rats. However, a clear understanding of the biological mechanisms underlying these differences remains elusive. The present study investigated whether sexual dimorphisms in cocaine-induced motor behavi...

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Veröffentlicht in:	Neuropharmacology 2004-04, Vol.46 (5), p.672-687
Hauptverfasser:	Festa, Eugene D., Russo, Scott J., Gazi, Farhad M., Niyomchai, Tipyamol, Kemen, Lynne M., Lin, Shen-Nan, Foltz, Rodger, Jenab, Shirzad, Quinones-Jenab, Vanya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biogenic Monoamines - blood Biogenic Monoamines - metabolism Brain - drug effects Brain - metabolism Cocaine Cocaine - blood Cocaine - pharmacokinetics Cocaine - pharmacology Dopamine Dose-Response Relationship, Drug Female Gender Male Metabolism Motor Activity - drug effects Motor Activity - physiology Rats Rats, Inbred F344 Serotonin Sex Sex Characteristics
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