NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter

A 5T/6T polymorphic site in the matrix metalloproteinase-3 (MMP-3) promoter has been identified as a repressor element involved in inhibiting induction of MMP-3 transcription by interleukin 1; and the 6T allele has been associated with decreased expression of MMP-3 as compared to the 5T allele. Zinc...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-03, Vol.316 (1), p.182-188
Hauptverfasser:	Borghaei, Ruth C, Rawlings, Jr, P Lyle, Javadi, Masoud, Woloshin, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites DNA-Binding Proteins - metabolism Enzyme Repression Fibroblasts - drug effects Fibroblasts - metabolism Gingiva - cytology Humans Interleukin-1 - pharmacology Matrix Metalloproteinase 3 - genetics NF-kappa B - metabolism NF-kappa B p50 Subunit Polymorphism, Genetic Promoter Regions, Genetic Repressor Proteins - metabolism Response Elements Transcription Factors - metabolism
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