Diazepam Promotes ATP Recovery and Prevents Cytochrome c Release in Hippocampal Slices After In Vitro Ischemia

: Benzodiazepines protect hippocampal neurons when administered within the first few hours after transient cerebral ischemia. Here, we examined the ability of diazepam to prevent early signals of cell injury (before cell death) after in vitro ischemia. Ischemia in vitro or in vivo causes a rapid dep...

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Veröffentlicht in:	Journal of neurochemistry 2000-09, Vol.75 (3), p.1242-1249
Hauptverfasser:	Galeffi, Francesca, Sinnar, Shamim, Schwartz‐Bloom, Rochelle D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals ATP Biological and medical sciences Brain Ischemia - metabolism Brain Ischemia - pathology Cytochrome c Cytochrome c Group - antagonists & inhibitors Cytochrome c Group - metabolism Cytosol - metabolism Diazepam Diazepam - pharmacology GABAA receptor Glucose - metabolism Glucose - pharmacology Hippocampal slice Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hypoxia, Brain - metabolism Immunohistochemistry In vitro ischemia In Vitro Techniques Male Medical sciences Microtubule-Associated Proteins - metabolism Mitochondria - metabolism Neurology Rats Rats, Sprague-Dawley Vascular diseases and vascular malformations of the nervous system
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