Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5

: The mature form of Alzheimer's β‐amyloid precursor protein (APP) is phosphorylated specifically at Thr668 in neurons. In mature neurons, phosphorylated APP is detected in neurites, with dephosphorylated APP being found mostly in the cell body. In vitro, active cyclin‐dependent kinase 5 (Cdk5)...

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Veröffentlicht in:	Journal of neurochemistry 2000-09, Vol.75 (3), p.1085-1091
Hauptverfasser:	Iijima, Ko‐ichi, Ando, Kanae, Takeda, Shizu, Satoh, Yasushi, Seki, Tatsunori, Itohara, Shigeyoshi, Greengard, Paul, Kirino, Yutaka, Nairn, Angus C., Suzuki, Toshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimer's β‐amyloid precursor protein Amyloid beta-Protein Precursor - chemistry Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Biological and medical sciences Brain - metabolism cdk5 protein Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Embryo, Mammalian Hippocampus - embryology Hippocampus - metabolism Lung - metabolism Male Medical sciences Mice Mice, Inbred C57BL Neurology Neurons - cytology Neurons - drug effects Neurons - metabolism Oligodeoxyribonucleotides, Antisense - pharmacology Organ Specificity Phosphorylation Protein phosphorylation Rats Rats, Wistar Spleen - metabolism Testis - metabolism Threonine
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