Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an update

The fibrohistiocytic tumors of intermediate malignancy are uncommon mesenchymal tumors, which typically occur in the skin and subcutis and which may pose significant problems for the dermatopathologist. This article reviews the clinical, histopathologic, and genetic features of dermatofibrosarcoma p...

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Veröffentlicht in:The American journal of dermatopathology 2004-04, Vol.26 (2), p.141-155
Hauptverfasser: Billings, Steven D, Folpe, Andrew L
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container_title The American journal of dermatopathology
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creator Billings, Steven D
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description The fibrohistiocytic tumors of intermediate malignancy are uncommon mesenchymal tumors, which typically occur in the skin and subcutis and which may pose significant problems for the dermatopathologist. This article reviews the clinical, histopathologic, and genetic features of dermatofibrosarcoma protuberans, giant cell fibroblastoma, angiomatoid (malignant) fibrous histiocytoma, plexiform fibrous histiocytoma, and soft tissue giant cell tumor (of low malignant potential). The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed.
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subjects Diagnosis, Differential
DNA, Neoplasm - analysis
Histiocytoma, Benign Fibrous - genetics
Histiocytoma, Benign Fibrous - pathology
Humans
Neoplasm Invasiveness - pathology
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - pathology
title Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an update
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