TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain
We have discovered a family of small secreted proteins in Homo sapiens and Mus musculus using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserve...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 2004-04, Vol.83 (4), p.727-734 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Tom Tang, Y Emtage, Peter Funk, Walter D Hu, Tianhua Arterburn, Matthew Park, Emily E.J Rupp, Fabio |
| description | We have discovered a family of small secreted proteins in
Homo sapiens and
Mus musculus using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In
H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. Sequence homology analyses reveal that TAFA proteins appear distantly related to MIP-1α, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions, with little expression seen in other tissues. |
| doi_str_mv | 10.1016/j.ygeno.2003.10.006 |
| format | Article |
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Homo sapiens and
Mus musculus using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In
H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. Sequence homology analyses reveal that TAFA proteins appear distantly related to MIP-1α, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions, with little expression seen in other tissues.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/j.ygeno.2003.10.006</identifier><identifier>PMID: 15028294</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Alternative Splicing ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Brain - metabolism ; CC chemokines ; Chemokine CCL3 ; Chemokine CCL4 ; Chemokines - genetics ; Chemokines - metabolism ; Cloning, Molecular ; Cluster analysis ; Conserved Sequence ; Cysteine - chemistry ; Cysteine - metabolism ; Cytokines ; DNA Primers - chemistry ; Expressed Sequence Tags ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes. Genome ; Genetics of eukaryotes. Biological and molecular evolution ; Homo sapiens ; Humans ; Intercellular signaling proteins ; Macrophage Inflammatory Proteins - metabolism ; Mice ; MIP-1α ; Models, Genetic ; Molecular and cellular biology ; Molecular cloning ; Molecular genetics ; Molecular Sequence Data ; Multigene Family ; Mus musculus ; Phylogeny ; Protein Isoforms ; Protein Sorting Signals ; Sequence Homology, Amino Acid ; Signal peptide ; Signal Transduction</subject><ispartof>Genomics (San Diego, Calif.), 2004-04, Vol.83 (4), p.727-734</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-c1b0760da9a27385d8d3bee4ef3e674dc9f6ed17cc41796730ca2067a301713d3</citedby><cites>FETCH-LOGICAL-c416t-c1b0760da9a27385d8d3bee4ef3e674dc9f6ed17cc41796730ca2067a301713d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygeno.2003.10.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15611788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15028294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tom Tang, Y</creatorcontrib><creatorcontrib>Emtage, Peter</creatorcontrib><creatorcontrib>Funk, Walter D</creatorcontrib><creatorcontrib>Hu, Tianhua</creatorcontrib><creatorcontrib>Arterburn, Matthew</creatorcontrib><creatorcontrib>Park, Emily E.J</creatorcontrib><creatorcontrib>Rupp, Fabio</creatorcontrib><title>TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>We have discovered a family of small secreted proteins in
Homo sapiens and
Mus musculus using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In
H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. Sequence homology analyses reveal that TAFA proteins appear distantly related to MIP-1α, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions, with little expression seen in other tissues.</description><subject>Alternative Splicing</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>CC chemokines</subject><subject>Chemokine CCL3</subject><subject>Chemokine CCL4</subject><subject>Chemokines - genetics</subject><subject>Chemokines - metabolism</subject><subject>Cloning, Molecular</subject><subject>Cluster analysis</subject><subject>Conserved Sequence</subject><subject>Cysteine - chemistry</subject><subject>Cysteine - metabolism</subject><subject>Cytokines</subject><subject>DNA Primers - chemistry</subject><subject>Expressed Sequence Tags</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes. Genome</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Homo sapiens</subject><subject>Humans</subject><subject>Intercellular signaling proteins</subject><subject>Macrophage Inflammatory Proteins - metabolism</subject><subject>Mice</subject><subject>MIP-1α</subject><subject>Models, Genetic</subject><subject>Molecular and cellular biology</subject><subject>Molecular cloning</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>Mus musculus</subject><subject>Phylogeny</subject><subject>Protein Isoforms</subject><subject>Protein Sorting Signals</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal peptide</subject><subject>Signal Transduction</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrGzEQhUVJqR23v6AQdElv645Wa0kbyMGEOi0EeknPQpZmG5m11pHWTvbfVxsbklN6Gmb43mN4j5CvDOYMmPi-mQ9_MXTzEoDnyxxAfCBTBqoulKjEGZmCUqqQi4pPyHlKGwCouSo_kQlbQKnKupoSvF-ullfU0NAdsKUJbcQeHW3M1rcDffL9A7VdSBgP-WqH1KMPSCMm7_aYqAluXPro7SjD513eku8C9YH2D0jX0fjwmXxsTJvwy2nOyJ_Vj_ubn8Xd79tfN8u7wlZM9IVla5ACnKlNKblaOOX4GrHChqOQlbN1I9AxaTMuayE5WFOCkIYDk4w7PiPfjr672D3m93q99cli25qA3T5pybKmZuV_wWyfo6pYBvkRtLFLKWKjd9FvTRw0Az3WoDf6pQY91jAecw1ZdXGy36-36F41p9wzcHkCTLKmbaIJ1qc3nGBMKpW56yOHObWDx6iT9RgsOh_R9tp1_t1H_gGULqdr</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Tom Tang, Y</creator><creator>Emtage, Peter</creator><creator>Funk, Walter D</creator><creator>Hu, Tianhua</creator><creator>Arterburn, Matthew</creator><creator>Park, Emily E.J</creator><creator>Rupp, Fabio</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain</title><author>Tom Tang, Y ; Emtage, Peter ; Funk, Walter D ; Hu, Tianhua ; Arterburn, Matthew ; Park, Emily E.J ; Rupp, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-c1b0760da9a27385d8d3bee4ef3e674dc9f6ed17cc41796730ca2067a301713d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alternative Splicing</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>CC chemokines</topic><topic>Chemokine CCL3</topic><topic>Chemokine CCL4</topic><topic>Chemokines - genetics</topic><topic>Chemokines - metabolism</topic><topic>Cloning, Molecular</topic><topic>Cluster analysis</topic><topic>Conserved Sequence</topic><topic>Cysteine - chemistry</topic><topic>Cysteine - metabolism</topic><topic>Cytokines</topic><topic>DNA Primers - chemistry</topic><topic>Expressed Sequence Tags</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Genes. Genome</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Homo sapiens</topic><topic>Humans</topic><topic>Intercellular signaling proteins</topic><topic>Macrophage Inflammatory Proteins - metabolism</topic><topic>Mice</topic><topic>MIP-1α</topic><topic>Models, Genetic</topic><topic>Molecular and cellular biology</topic><topic>Molecular cloning</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>Mus musculus</topic><topic>Phylogeny</topic><topic>Protein Isoforms</topic><topic>Protein Sorting Signals</topic><topic>Sequence Homology, Amino Acid</topic><topic>Signal peptide</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tom Tang, Y</creatorcontrib><creatorcontrib>Emtage, Peter</creatorcontrib><creatorcontrib>Funk, Walter D</creatorcontrib><creatorcontrib>Hu, Tianhua</creatorcontrib><creatorcontrib>Arterburn, Matthew</creatorcontrib><creatorcontrib>Park, Emily E.J</creatorcontrib><creatorcontrib>Rupp, Fabio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tom Tang, Y</au><au>Emtage, Peter</au><au>Funk, Walter D</au><au>Hu, Tianhua</au><au>Arterburn, Matthew</au><au>Park, Emily E.J</au><au>Rupp, Fabio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>83</volume><issue>4</issue><spage>727</spage><epage>734</epage><pages>727-734</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>We have discovered a family of small secreted proteins in
Homo sapiens and
Mus musculus using a novel database searching strategy. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In
H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. Sequence homology analyses reveal that TAFA proteins appear distantly related to MIP-1α, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions, with little expression seen in other tissues.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>15028294</pmid><doi>10.1016/j.ygeno.2003.10.006</doi><tpages>8</tpages></addata></record> |
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| subjects | Alternative Splicing Amino Acid Sequence Animals Biological and medical sciences Brain - metabolism CC chemokines Chemokine CCL3 Chemokine CCL4 Chemokines - genetics Chemokines - metabolism Cloning, Molecular Cluster analysis Conserved Sequence Cysteine - chemistry Cysteine - metabolism Cytokines DNA Primers - chemistry Expressed Sequence Tags Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes. Genome Genetics of eukaryotes. Biological and molecular evolution Homo sapiens Humans Intercellular signaling proteins Macrophage Inflammatory Proteins - metabolism Mice MIP-1α Models, Genetic Molecular and cellular biology Molecular cloning Molecular genetics Molecular Sequence Data Multigene Family Mus musculus Phylogeny Protein Isoforms Protein Sorting Signals Sequence Homology, Amino Acid Signal peptide Signal Transduction |
| title | TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain |
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