Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation
PURPOSE: To evaluate the correlation between interocular difference in progression of glaucomatous damage and interocular differences in retrobulbar blood flow. METHODS: On the basis of a retrospective analysis of visual fields, progressive damage was identified in 20 patients with primary open-angl...
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| Veröffentlicht in: | American journal of ophthalmology 2000-06, Vol.129 (6), p.728-733 |
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| container_title | American journal of ophthalmology |
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| creator | Schumann, Joerg Orgül, Selim Gugleta, Konstantin Dubler, Barbara Flammer, Josef |
| description | PURPOSE:
To evaluate the correlation between interocular difference in progression of glaucomatous damage and interocular differences in retrobulbar blood flow.
METHODS:
On the basis of a retrospective analysis of visual fields, progressive damage was identified in 20 patients with primary open-angle glaucoma. As a parameter of interocular difference in progression of visual field damage, the angle (gamma) between the regression lines of the visual field index mean defect over time per eye was calculated for each subject. The relationship between the angle gamma and interocular differences in intraocular pressure and retrobulbar color Doppler imaging parameters was analyzed by a multiple linear regression analysis in a stepwise forward approach.
RESULTS:
With larger interocular differences in progression of glaucomatous damage, lower mean blood flow velocities in the ophthalmic artery (partial
r = −.69;
P < .0016), higher resistivity indices in the central retinal artery (partial
r = .48;
P < .0456), and higher peak systolic velocities in the ophthalmic artery (partial
r = .52;
P < .0285) were noted in the eyes with more marked progression of damage (multiple
r = .71;
P < .0099). Interocular differences in progression of visual field damage were not related to intraocular pressure or extent of visual field damage.
CONCLUSION:
Independent of the extent of the interocular difference in glaucomatous damage and intraocular pressure, interocular difference in progression of glaucomatous visual field damage correlates with interocular difference in retrobulbar hemodynamic parameters. |
| doi_str_mv | 10.1016/S0002-9394(99)00481-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71730390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000293949900481X</els_id><sourcerecordid>71730390</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-4f461e9c475489a1f73139383010db27e483c8898609611bcca8d20893d8dec03</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EotvCTwDlgFA5BMbrNPGcKlTxUakSB0DqzXImk2KUjcvYAfHvcbor4IDEaWTNM--MH6WeaHipQbevPgLAtkaDzSniC4DG6vr6ntpo22GtLer7avMbOVLHKX0tz7ZruofqSANuW7SwUflyziyRlslLNYRxZOGZuApzdSvxRjilEOcqjtXN5BeKO19RFOHJZ07Vj5C_FPRfCWmNEM4S-2XqS4uCrEwucY_Ug9FPiR8f6on6_PbNp4v39dWHd5cXr69qMgi5bsam1YzUdGeNRa_HzmiDxhrQMPTbjhtryFq0LWCrdU_k7bAFi2awAxOYE_V8n1u-8m3hlN0uJOJp8jPHJblOdwbKqgKe7UGSmJLw6G4l7Lz8dBrcqtvd6XarS4fo7nS76zL39LBg6Xc8_DW191uAZwfAJ_LTKH6mkP5wJcbatmDne4yLje-BxSUKq8UhCFN2Qwz_ueQXoH-efA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71730390</pqid></control><display><type>article</type><title>Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Schumann, Joerg ; Orgül, Selim ; Gugleta, Konstantin ; Dubler, Barbara ; Flammer, Josef</creator><creatorcontrib>Schumann, Joerg ; Orgül, Selim ; Gugleta, Konstantin ; Dubler, Barbara ; Flammer, Josef</creatorcontrib><description>PURPOSE:
To evaluate the correlation between interocular difference in progression of glaucomatous damage and interocular differences in retrobulbar blood flow.
METHODS:
On the basis of a retrospective analysis of visual fields, progressive damage was identified in 20 patients with primary open-angle glaucoma. As a parameter of interocular difference in progression of visual field damage, the angle (gamma) between the regression lines of the visual field index mean defect over time per eye was calculated for each subject. The relationship between the angle gamma and interocular differences in intraocular pressure and retrobulbar color Doppler imaging parameters was analyzed by a multiple linear regression analysis in a stepwise forward approach.
RESULTS:
With larger interocular differences in progression of glaucomatous damage, lower mean blood flow velocities in the ophthalmic artery (partial
r = −.69;
P < .0016), higher resistivity indices in the central retinal artery (partial
r = .48;
P < .0456), and higher peak systolic velocities in the ophthalmic artery (partial
r = .52;
P < .0285) were noted in the eyes with more marked progression of damage (multiple
r = .71;
P < .0099). Interocular differences in progression of visual field damage were not related to intraocular pressure or extent of visual field damage.
CONCLUSION:
Independent of the extent of the interocular difference in glaucomatous damage and intraocular pressure, interocular difference in progression of glaucomatous visual field damage correlates with interocular difference in retrobulbar hemodynamic parameters.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(99)00481-X</identifier><identifier>PMID: 10926980</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Blood Circulation ; Blood Flow Velocity ; Disease Progression ; Eye - diagnostic imaging ; Eye - physiopathology ; Glaucoma and intraocular pressure ; Glaucoma, Open-Angle - diagnostic imaging ; Glaucoma, Open-Angle - physiopathology ; Humans ; Intraocular Pressure ; Medical sciences ; Middle Aged ; Ophthalmic Artery - diagnostic imaging ; Ophthalmic Artery - physiopathology ; Ophthalmology ; Orbit - blood supply ; Orbit - diagnostic imaging ; Retinal Artery - diagnostic imaging ; Retinal Artery - physiopathology ; Ultrasonography, Doppler, Color ; Vision Disorders - physiopathology ; Visual Fields</subject><ispartof>American journal of ophthalmology, 2000-06, Vol.129 (6), p.728-733</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-4f461e9c475489a1f73139383010db27e483c8898609611bcca8d20893d8dec03</citedby><cites>FETCH-LOGICAL-c390t-4f461e9c475489a1f73139383010db27e483c8898609611bcca8d20893d8dec03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9394(99)00481-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1481886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10926980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schumann, Joerg</creatorcontrib><creatorcontrib>Orgül, Selim</creatorcontrib><creatorcontrib>Gugleta, Konstantin</creatorcontrib><creatorcontrib>Dubler, Barbara</creatorcontrib><creatorcontrib>Flammer, Josef</creatorcontrib><title>Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>PURPOSE:
To evaluate the correlation between interocular difference in progression of glaucomatous damage and interocular differences in retrobulbar blood flow.
METHODS:
On the basis of a retrospective analysis of visual fields, progressive damage was identified in 20 patients with primary open-angle glaucoma. As a parameter of interocular difference in progression of visual field damage, the angle (gamma) between the regression lines of the visual field index mean defect over time per eye was calculated for each subject. The relationship between the angle gamma and interocular differences in intraocular pressure and retrobulbar color Doppler imaging parameters was analyzed by a multiple linear regression analysis in a stepwise forward approach.
RESULTS:
With larger interocular differences in progression of glaucomatous damage, lower mean blood flow velocities in the ophthalmic artery (partial
r = −.69;
P < .0016), higher resistivity indices in the central retinal artery (partial
r = .48;
P < .0456), and higher peak systolic velocities in the ophthalmic artery (partial
r = .52;
P < .0285) were noted in the eyes with more marked progression of damage (multiple
r = .71;
P < .0099). Interocular differences in progression of visual field damage were not related to intraocular pressure or extent of visual field damage.
CONCLUSION:
Independent of the extent of the interocular difference in glaucomatous damage and intraocular pressure, interocular difference in progression of glaucomatous visual field damage correlates with interocular difference in retrobulbar hemodynamic parameters.</description><subject>Biological and medical sciences</subject><subject>Blood Circulation</subject><subject>Blood Flow Velocity</subject><subject>Disease Progression</subject><subject>Eye - diagnostic imaging</subject><subject>Eye - physiopathology</subject><subject>Glaucoma and intraocular pressure</subject><subject>Glaucoma, Open-Angle - diagnostic imaging</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmic Artery - diagnostic imaging</subject><subject>Ophthalmic Artery - physiopathology</subject><subject>Ophthalmology</subject><subject>Orbit - blood supply</subject><subject>Orbit - diagnostic imaging</subject><subject>Retinal Artery - diagnostic imaging</subject><subject>Retinal Artery - physiopathology</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Vision Disorders - physiopathology</subject><subject>Visual Fields</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwDlgFA5BMbrNPGcKlTxUakSB0DqzXImk2KUjcvYAfHvcbor4IDEaWTNM--MH6WeaHipQbevPgLAtkaDzSniC4DG6vr6ntpo22GtLer7avMbOVLHKX0tz7ZruofqSANuW7SwUflyziyRlslLNYRxZOGZuApzdSvxRjilEOcqjtXN5BeKO19RFOHJZ07Vj5C_FPRfCWmNEM4S-2XqS4uCrEwucY_Ug9FPiR8f6on6_PbNp4v39dWHd5cXr69qMgi5bsam1YzUdGeNRa_HzmiDxhrQMPTbjhtryFq0LWCrdU_k7bAFi2awAxOYE_V8n1u-8m3hlN0uJOJp8jPHJblOdwbKqgKe7UGSmJLw6G4l7Lz8dBrcqtvd6XarS4fo7nS76zL39LBg6Xc8_DW191uAZwfAJ_LTKH6mkP5wJcbatmDne4yLje-BxSUKq8UhCFN2Qwz_ueQXoH-efA</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Schumann, Joerg</creator><creator>Orgül, Selim</creator><creator>Gugleta, Konstantin</creator><creator>Dubler, Barbara</creator><creator>Flammer, Josef</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation</title><author>Schumann, Joerg ; Orgül, Selim ; Gugleta, Konstantin ; Dubler, Barbara ; Flammer, Josef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-4f461e9c475489a1f73139383010db27e483c8898609611bcca8d20893d8dec03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Blood Circulation</topic><topic>Blood Flow Velocity</topic><topic>Disease Progression</topic><topic>Eye - diagnostic imaging</topic><topic>Eye - physiopathology</topic><topic>Glaucoma and intraocular pressure</topic><topic>Glaucoma, Open-Angle - diagnostic imaging</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmic Artery - diagnostic imaging</topic><topic>Ophthalmic Artery - physiopathology</topic><topic>Ophthalmology</topic><topic>Orbit - blood supply</topic><topic>Orbit - diagnostic imaging</topic><topic>Retinal Artery - diagnostic imaging</topic><topic>Retinal Artery - physiopathology</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Vision Disorders - physiopathology</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schumann, Joerg</creatorcontrib><creatorcontrib>Orgül, Selim</creatorcontrib><creatorcontrib>Gugleta, Konstantin</creatorcontrib><creatorcontrib>Dubler, Barbara</creatorcontrib><creatorcontrib>Flammer, Josef</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schumann, Joerg</au><au>Orgül, Selim</au><au>Gugleta, Konstantin</au><au>Dubler, Barbara</au><au>Flammer, Josef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>129</volume><issue>6</issue><spage>728</spage><epage>733</epage><pages>728-733</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>PURPOSE:
To evaluate the correlation between interocular difference in progression of glaucomatous damage and interocular differences in retrobulbar blood flow.
METHODS:
On the basis of a retrospective analysis of visual fields, progressive damage was identified in 20 patients with primary open-angle glaucoma. As a parameter of interocular difference in progression of visual field damage, the angle (gamma) between the regression lines of the visual field index mean defect over time per eye was calculated for each subject. The relationship between the angle gamma and interocular differences in intraocular pressure and retrobulbar color Doppler imaging parameters was analyzed by a multiple linear regression analysis in a stepwise forward approach.
RESULTS:
With larger interocular differences in progression of glaucomatous damage, lower mean blood flow velocities in the ophthalmic artery (partial
r = −.69;
P < .0016), higher resistivity indices in the central retinal artery (partial
r = .48;
P < .0456), and higher peak systolic velocities in the ophthalmic artery (partial
r = .52;
P < .0285) were noted in the eyes with more marked progression of damage (multiple
r = .71;
P < .0099). Interocular differences in progression of visual field damage were not related to intraocular pressure or extent of visual field damage.
CONCLUSION:
Independent of the extent of the interocular difference in glaucomatous damage and intraocular pressure, interocular difference in progression of glaucomatous visual field damage correlates with interocular difference in retrobulbar hemodynamic parameters.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10926980</pmid><doi>10.1016/S0002-9394(99)00481-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Blood Circulation Blood Flow Velocity Disease Progression Eye - diagnostic imaging Eye - physiopathology Glaucoma and intraocular pressure Glaucoma, Open-Angle - diagnostic imaging Glaucoma, Open-Angle - physiopathology Humans Intraocular Pressure Medical sciences Middle Aged Ophthalmic Artery - diagnostic imaging Ophthalmic Artery - physiopathology Ophthalmology Orbit - blood supply Orbit - diagnostic imaging Retinal Artery - diagnostic imaging Retinal Artery - physiopathology Ultrasonography, Doppler, Color Vision Disorders - physiopathology Visual Fields |
| title | Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation |
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