The many faces of β-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

Beta-transducin repeats-containing proteins ( β -TrCP) serve as the substrate recognition subunits for the SCF β -TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pa...

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Veröffentlicht in:	Oncogene 2004-03, Vol.23 (11), p.2028-2036
Hauptverfasser:	Fuchs, Serge Y, Spiegelman, Vladimir S, Suresh Kumar, K G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis beta-Transducin Repeat-Containing Proteins - genetics beta-Transducin Repeat-Containing Proteins - metabolism Cell Biology Cell division Cell survival Gene Expression Regulation, Neoplastic Human Genetics Humans Internal Medicine Ligases - metabolism Medicine Medicine & Public Health Models, Biological Neoplasms - genetics Oncology review Signal transduction Substrate Specificity Transducin Tumorigenesis Ubiquitin Ubiquitin-protein ligase Ubiquitins - metabolism
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