Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p ® and carboxymethylcellulose

The residence time of apomorphine mucoadhesive preparations incorporating 99mTc labeled colloidal albumin in rabbit nasal cavity was evaluated by gamma scintigraphy. This technique was used to compare the nasal clearance of preparations based either on Carbopol 971P ® or lactose (control), each with...

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Veröffentlicht in:	Journal of controlled release 2000-08, Vol.68 (2), p.207-214
Hauptverfasser:	Ugwoke, Michael Ikechukwu, Agu, Remigius Uchenna, Vanbilloen, Hubert, Baetens, Jan, Augustijns, Patrick, Verbeke, Norbert, Mortelmans, Luc, Verbruggen, Alfons, Kinget, Renaat, Bormans, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	99mTc labeled colloidal albumin Acrylic Resins Animals Apomorphine Apomorphine - pharmacology Biological and medical sciences Carbopol Carboxymethylcellulose Carboxymethylcellulose Sodium - administration & dosage Carboxymethylcellulose Sodium - pharmacokinetics Catecholaminergic system Drug Delivery Systems Gamma scintigraphy General pharmacology Male Medical sciences Mucociliary Clearance Nasal drug delivery Nasal Mucosa - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyvinyls - administration & dosage Polyvinyls - pharmacokinetics Rabbits Technetium
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