Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

Growth factors and their transmembrane receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis, including multiple stages of cancer. The amplitude and kinetics of signaling by growth factor receptors are determined by an endocytic process, which sorts...

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Veröffentlicht in:Oncogene 2004-03, Vol.23 (11), p.2057-2070
Hauptverfasser: Marmor, Mina D, Yarden, Yosef
Format: Artikel
Sprache:eng
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