Factors affecting clinical outcome in gastrostomy-fed children with cystic fibrosis
In order to assess the effects of gastrostomy feeding on nutritional status, respiratory function, and survival in children with cystic fibrosis (CF), we studied all patients undergoing gastrostomy between 1989–1997 at the Royal Children's Hospital, Melbourne. Clinical information was collected...
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| Veröffentlicht in: | Pediatric pulmonology 2004-04, Vol.37 (4), p.324-329 |
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| creator | Oliver, Mark R. Heine, Ralf G. Ng, Chi Hang Volders, Evelyn Olinsky, Anthony |
| description | In order to assess the effects of gastrostomy feeding on nutritional status, respiratory function, and survival in children with cystic fibrosis (CF), we studied all patients undergoing gastrostomy between 1989–1997 at the Royal Children's Hospital, Melbourne. Clinical information was collected from medical records, including serial measurements of weight‐for‐age standard deviation scores (WAZ) and forced expired volume in 1 sec (FEV1) (percent predicted). Measurements were compared for 2 years before and 2 years after gastrostomy placement. Data on gastroesophageal reflux (GER), adherence to the gastrostomy feeding program, and sputum culture were also assessed. Of 37 children (22 male; mean age, 11.6 ± 4.8 years; range, 3–20), 11 died during the study period (7 female, 4 male). Female patients were more likely to die within 2 years of gastrostomy placement (OR = 3.9; 95% CI, 0.72–23.2; P = 0.07). Mortality was significantly associated with a WAZ score |
| doi_str_mv | 10.1002/ppul.10321 |
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Clinical information was collected from medical records, including serial measurements of weight‐for‐age standard deviation scores (WAZ) and forced expired volume in 1 sec (FEV1) (percent predicted). Measurements were compared for 2 years before and 2 years after gastrostomy placement. Data on gastroesophageal reflux (GER), adherence to the gastrostomy feeding program, and sputum culture were also assessed. Of 37 children (22 male; mean age, 11.6 ± 4.8 years; range, 3–20), 11 died during the study period (7 female, 4 male). Female patients were more likely to die within 2 years of gastrostomy placement (OR = 3.9; 95% CI, 0.72–23.2; P = 0.07). Mortality was significantly associated with a WAZ score <−2 (OR = 10.7; 95% CI, 1.07–466.6; P = 0.02) and predicted FEV1 <50% (OR = 10.8; 95% CI, 1.07–512.9; P = 0.02) at time of gastrostomy. Patients with clinical evidence of GER (n = 11) had significantly lower weight gain after gastrostomy (delta WAZ, −0.32 ± 0.26 vs. 0.03 ± 0.39; P = 0.03). In conclusion, the presence of advanced lung disease, GER, and female gender were factors associated with a poor clinical outcome after gastrostomy placement. Pediatr Pulmonol. 2004; 37:324–329. © 2004 Wiely‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.10321</identifier><identifier>PMID: 15022129</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Body Weight - physiology ; Child ; Child, Preschool ; cystic fibrosis ; Cystic Fibrosis - mortality ; Cystic Fibrosis - physiopathology ; Cystic Fibrosis - therapy ; Enteral Nutrition ; Female ; Forced Expiratory Volume - physiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - physiopathology ; Gastrostomy ; General aspects ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; nutrition ; Other diseases. Semiology ; Outcome Assessment (Health Care) ; Pneumology ; Predictive Value of Tests ; pulmonary function ; Retrospective Studies ; Sex Factors ; survival</subject><ispartof>Pediatric pulmonology, 2004-04, Vol.37 (4), p.324-329</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Wiely-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3931-1ebae3e9c4f1c4fd5aaacb4c63214c6c1e1bfdac53286b48e428106d36fd108b3</citedby><cites>FETCH-LOGICAL-c3931-1ebae3e9c4f1c4fd5aaacb4c63214c6c1e1bfdac53286b48e428106d36fd108b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.10321$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.10321$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15620536$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15022129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliver, Mark R.</creatorcontrib><creatorcontrib>Heine, Ralf G.</creatorcontrib><creatorcontrib>Ng, Chi Hang</creatorcontrib><creatorcontrib>Volders, Evelyn</creatorcontrib><creatorcontrib>Olinsky, Anthony</creatorcontrib><title>Factors affecting clinical outcome in gastrostomy-fed children with cystic fibrosis</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>In order to assess the effects of gastrostomy feeding on nutritional status, respiratory function, and survival in children with cystic fibrosis (CF), we studied all patients undergoing gastrostomy between 1989–1997 at the Royal Children's Hospital, Melbourne. Clinical information was collected from medical records, including serial measurements of weight‐for‐age standard deviation scores (WAZ) and forced expired volume in 1 sec (FEV1) (percent predicted). Measurements were compared for 2 years before and 2 years after gastrostomy placement. Data on gastroesophageal reflux (GER), adherence to the gastrostomy feeding program, and sputum culture were also assessed. Of 37 children (22 male; mean age, 11.6 ± 4.8 years; range, 3–20), 11 died during the study period (7 female, 4 male). Female patients were more likely to die within 2 years of gastrostomy placement (OR = 3.9; 95% CI, 0.72–23.2; P = 0.07). Mortality was significantly associated with a WAZ score <−2 (OR = 10.7; 95% CI, 1.07–466.6; P = 0.02) and predicted FEV1 <50% (OR = 10.8; 95% CI, 1.07–512.9; P = 0.02) at time of gastrostomy. Patients with clinical evidence of GER (n = 11) had significantly lower weight gain after gastrostomy (delta WAZ, −0.32 ± 0.26 vs. 0.03 ± 0.39; P = 0.03). In conclusion, the presence of advanced lung disease, GER, and female gender were factors associated with a poor clinical outcome after gastrostomy placement. Pediatr Pulmonol. 2004; 37:324–329. © 2004 Wiely‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>cystic fibrosis</subject><subject>Cystic Fibrosis - mortality</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Cystic Fibrosis - therapy</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Gastrostomy</subject><subject>General aspects</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>nutrition</subject><subject>Other diseases. Semiology</subject><subject>Outcome Assessment (Health Care)</subject><subject>Pneumology</subject><subject>Predictive Value of Tests</subject><subject>pulmonary function</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>survival</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtu1DAUQC0EokPLhg9A3sACKa2vHTvJEg30IY3aolLBznKc69aQx2A7KvP3eDrDY8XC9pV87usQ8grYMTDGT9bruc-R4PCELIA1TcHKRj0li7qSslC1EgfkRYzfGMt_DTwnByAZ58CbBbk5NTZNIVLjHNrkxztqez96a3o6zclOA1I_0jsTU5himoZN4bCj9t73XcCRPvh0T-0mJm-p821mfDwiz5zpI77cv4fk9vTj5-V5sbo6u1i-XxVWNAIKwNagwMaWDvLppDHGtqVVeZF8W0BoXWesFLxWbVljyWtgqhPKdcDqVhySt7u66zD9mDEmPfhose_NiNMcdQUV3yrI4LsdaPN8MaDT6-AHEzYamN4q1FuF-lFhhl_vq87tgN1fdO8sA2_2gIlZkwtmtD7-wynOpFCZgx334Hvc_Kelvr6-Xf1uXuxyfEz480-OCd-1qkQl9ZfLM3356YNcKin0V_ELsjmZtg</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Oliver, Mark R.</creator><creator>Heine, Ralf G.</creator><creator>Ng, Chi Hang</creator><creator>Volders, Evelyn</creator><creator>Olinsky, Anthony</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Factors affecting clinical outcome in gastrostomy-fed children with cystic fibrosis</title><author>Oliver, Mark R. ; Heine, Ralf G. ; Ng, Chi Hang ; Volders, Evelyn ; Olinsky, Anthony</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3931-1ebae3e9c4f1c4fd5aaacb4c63214c6c1e1bfdac53286b48e428106d36fd108b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>cystic fibrosis</topic><topic>Cystic Fibrosis - mortality</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Cystic Fibrosis - therapy</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Gastrostomy</topic><topic>General aspects</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>nutrition</topic><topic>Other diseases. Semiology</topic><topic>Outcome Assessment (Health Care)</topic><topic>Pneumology</topic><topic>Predictive Value of Tests</topic><topic>pulmonary function</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliver, Mark R.</creatorcontrib><creatorcontrib>Heine, Ralf G.</creatorcontrib><creatorcontrib>Ng, Chi Hang</creatorcontrib><creatorcontrib>Volders, Evelyn</creatorcontrib><creatorcontrib>Olinsky, Anthony</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliver, Mark R.</au><au>Heine, Ralf G.</au><au>Ng, Chi Hang</au><au>Volders, Evelyn</au><au>Olinsky, Anthony</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting clinical outcome in gastrostomy-fed children with cystic fibrosis</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2004-04</date><risdate>2004</risdate><volume>37</volume><issue>4</issue><spage>324</spage><epage>329</epage><pages>324-329</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>In order to assess the effects of gastrostomy feeding on nutritional status, respiratory function, and survival in children with cystic fibrosis (CF), we studied all patients undergoing gastrostomy between 1989–1997 at the Royal Children's Hospital, Melbourne. Clinical information was collected from medical records, including serial measurements of weight‐for‐age standard deviation scores (WAZ) and forced expired volume in 1 sec (FEV1) (percent predicted). Measurements were compared for 2 years before and 2 years after gastrostomy placement. Data on gastroesophageal reflux (GER), adherence to the gastrostomy feeding program, and sputum culture were also assessed. Of 37 children (22 male; mean age, 11.6 ± 4.8 years; range, 3–20), 11 died during the study period (7 female, 4 male). Female patients were more likely to die within 2 years of gastrostomy placement (OR = 3.9; 95% CI, 0.72–23.2; P = 0.07). Mortality was significantly associated with a WAZ score <−2 (OR = 10.7; 95% CI, 1.07–466.6; P = 0.02) and predicted FEV1 <50% (OR = 10.8; 95% CI, 1.07–512.9; P = 0.02) at time of gastrostomy. Patients with clinical evidence of GER (n = 11) had significantly lower weight gain after gastrostomy (delta WAZ, −0.32 ± 0.26 vs. 0.03 ± 0.39; P = 0.03). In conclusion, the presence of advanced lung disease, GER, and female gender were factors associated with a poor clinical outcome after gastrostomy placement. Pediatr Pulmonol. 2004; 37:324–329. © 2004 Wiely‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15022129</pmid><doi>10.1002/ppul.10321</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Body Weight - physiology Child Child, Preschool cystic fibrosis Cystic Fibrosis - mortality Cystic Fibrosis - physiopathology Cystic Fibrosis - therapy Enteral Nutrition Female Forced Expiratory Volume - physiology Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - physiopathology Gastrostomy General aspects Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences nutrition Other diseases. Semiology Outcome Assessment (Health Care) Pneumology Predictive Value of Tests pulmonary function Retrospective Studies Sex Factors survival |
| title | Factors affecting clinical outcome in gastrostomy-fed children with cystic fibrosis |
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