Influence of antigenic forms and adjuvants on protection against a lethal infection of Aujeszky’s disease virus
The influence of antigenic forms and adjuvant types on protection against a lethal infection of Aujeszky’s disease virus (ADV) in mice was investigated. Antiviral IgG2a antibody response against particulate (inactivated ADV) and soluble antigen (ADV solubilized with deoxychorate–Na) in approximate o...
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| Veröffentlicht in: | Vaccine 2000-08, Vol.19 (1), p.54-58 |
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| creator | Katayama, Shigeji Oda, Kenji Ohgitani, Toshiaki |
| description | The influence of antigenic forms and adjuvant types on protection against a lethal infection of Aujeszky’s disease virus (ADV) in mice was investigated. Antiviral IgG2a antibody response against particulate (inactivated ADV) and soluble antigen (ADV solubilized with deoxychorate–Na) in approximate order of extent was ISA70>QS-21>positively charged liposome>negatively charged liposome>weak negatively charged liposome>ISA25>lablabside F saponin>aluminum phosphate gel>non adjuvant. Particulate antigen induced higher IgG2a antibody production than soluble antigen. Particulate antigen combined with ISA70, ISA25 or positively charged liposome gave 100, 50 and 40% protection to mice, respectively. In contrast, soluble antigen plus ISA70 conferred 30% protection on mice. Immunogens using the other adjuvants gave ≤20% protection to mice. These results indicate that a combination of particulate antigen and an appropriate adjuvant effectively induces the production of antiviral IgG2a antibody and provides protection against a lethal ADV infection in mice. |
| doi_str_mv | 10.1016/S0264-410X(00)00150-X |
| format | Article |
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Antiviral IgG2a antibody response against particulate (inactivated ADV) and soluble antigen (ADV solubilized with deoxychorate–Na) in approximate order of extent was ISA70>QS-21>positively charged liposome>negatively charged liposome>weak negatively charged liposome>ISA25>lablabside F saponin>aluminum phosphate gel>non adjuvant. Particulate antigen induced higher IgG2a antibody production than soluble antigen. Particulate antigen combined with ISA70, ISA25 or positively charged liposome gave 100, 50 and 40% protection to mice, respectively. In contrast, soluble antigen plus ISA70 conferred 30% protection on mice. Immunogens using the other adjuvants gave ≤20% protection to mice. 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Psychology ; Herpesvirus 1, Suid - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Particulate antigen ; Protection ; Pseudorabies - immunology ; Pseudorabies - prevention & control ; Soluble antigen ; Treatment Outcome ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology</subject><ispartof>Vaccine, 2000-08, Vol.19 (1), p.54-58</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c338t-6f1303fc667dcfc3ec41586bcd17e8878596f238c1aa518bf0f92c85c7d037e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X0000150X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64363,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1482308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10924786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katayama, Shigeji</creatorcontrib><creatorcontrib>Oda, Kenji</creatorcontrib><creatorcontrib>Ohgitani, Toshiaki</creatorcontrib><title>Influence of antigenic forms and adjuvants on protection against a lethal infection of Aujeszky’s disease virus</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The influence of antigenic forms and adjuvant types on protection against a lethal infection of Aujeszky’s disease virus (ADV) in mice was investigated. Antiviral IgG2a antibody response against particulate (inactivated ADV) and soluble antigen (ADV solubilized with deoxychorate–Na) in approximate order of extent was ISA70>QS-21>positively charged liposome>negatively charged liposome>weak negatively charged liposome>ISA25>lablabside F saponin>aluminum phosphate gel>non adjuvant. Particulate antigen induced higher IgG2a antibody production than soluble antigen. Particulate antigen combined with ISA70, ISA25 or positively charged liposome gave 100, 50 and 40% protection to mice, respectively. In contrast, soluble antigen plus ISA70 conferred 30% protection on mice. Immunogens using the other adjuvants gave ≤20% protection to mice. These results indicate that a combination of particulate antigen and an appropriate adjuvant effectively induces the production of antiviral IgG2a antibody and provides protection against a lethal ADV infection in mice.</description><subject>Adjuvant</subject><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Animals</subject><subject>Antigens, Viral - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herpesvirus 1, Suid - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Particulate antigen</subject><subject>Protection</subject><subject>Pseudorabies - immunology</subject><subject>Pseudorabies - prevention & control</subject><subject>Soluble antigen</subject><subject>Treatment Outcome</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEQgC0EoqHwCCAfEILDwni9azunqqooVKrUAyDlZjnecXHYeFvPbqRy4jX6en2SOk1EuXGyrfnm7zNjrwV8FCDUp29Qq6ZqBCzeA3wAEC1UiydsJoyWVd0K85TN_iIH7AXRCgBaKebP2YGAed1oo2bs-iyFfsLkkQ-BuzTGS0zR8zDkNZV3x123mjYlQHxI_CoPI_oxlqu7dDHRyB3vcfzpeh5T2IdKpeNphfT7183dn1viXSR0hHwT80Qv2bPgesJX-_OQ_Tj9_P3ka3V-8eXs5Pi88lKasVJBSJDBK6U7H7xE34jWqKXvhEZjtGnnKtTSeOFc2XYZIMxrb1qvO5AaW3nI3u3qlpmvJ6TRriN57HuXcJjIaqFro4wqYLsDfR6IMgZ7lePa5RsrwG5d2wfXdivSAtgH13ZR8t7sG0zLNXb_ZO3kFuDtHnDkXR-ySz7SI9eYWoIp2NEOw2JjEzFb8nH7I13MRajthvifSe4BS4SeUw</recordid><startdate>20000815</startdate><enddate>20000815</enddate><creator>Katayama, Shigeji</creator><creator>Oda, Kenji</creator><creator>Ohgitani, Toshiaki</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000815</creationdate><title>Influence of antigenic forms and adjuvants on protection against a lethal infection of Aujeszky’s disease virus</title><author>Katayama, Shigeji ; Oda, Kenji ; Ohgitani, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-6f1303fc667dcfc3ec41586bcd17e8878596f238c1aa518bf0f92c85c7d037e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adjuvant</topic><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Animals</topic><topic>Antigens, Viral - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herpesvirus 1, Suid - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Particulate antigen</topic><topic>Protection</topic><topic>Pseudorabies - immunology</topic><topic>Pseudorabies - prevention & control</topic><topic>Soluble antigen</topic><topic>Treatment Outcome</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katayama, Shigeji</creatorcontrib><creatorcontrib>Oda, Kenji</creatorcontrib><creatorcontrib>Ohgitani, Toshiaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katayama, Shigeji</au><au>Oda, Kenji</au><au>Ohgitani, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of antigenic forms and adjuvants on protection against a lethal infection of Aujeszky’s disease virus</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2000-08-15</date><risdate>2000</risdate><volume>19</volume><issue>1</issue><spage>54</spage><epage>58</epage><pages>54-58</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The influence of antigenic forms and adjuvant types on protection against a lethal infection of Aujeszky’s disease virus (ADV) in mice was investigated. Antiviral IgG2a antibody response against particulate (inactivated ADV) and soluble antigen (ADV solubilized with deoxychorate–Na) in approximate order of extent was ISA70>QS-21>positively charged liposome>negatively charged liposome>weak negatively charged liposome>ISA25>lablabside F saponin>aluminum phosphate gel>non adjuvant. Particulate antigen induced higher IgG2a antibody production than soluble antigen. Particulate antigen combined with ISA70, ISA25 or positively charged liposome gave 100, 50 and 40% protection to mice, respectively. In contrast, soluble antigen plus ISA70 conferred 30% protection on mice. Immunogens using the other adjuvants gave ≤20% protection to mice. These results indicate that a combination of particulate antigen and an appropriate adjuvant effectively induces the production of antiviral IgG2a antibody and provides protection against a lethal ADV infection in mice.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10924786</pmid><doi>10.1016/S0264-410X(00)00150-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | Vaccine, 2000-08, Vol.19 (1), p.54-58 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adjuvant Adjuvants, Immunologic - administration & dosage Animals Antigens, Viral - administration & dosage Biological and medical sciences Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Herpesvirus 1, Suid - immunology Mice Mice, Inbred BALB C Microbiology Particulate antigen Protection Pseudorabies - immunology Pseudorabies - prevention & control Soluble antigen Treatment Outcome Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology |
| title | Influence of antigenic forms and adjuvants on protection against a lethal infection of Aujeszky’s disease virus |
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