Ischaemic preconditioning has a beneficial effect on left ventricular haemodynamic function after a coronary artery biopass grafting operation
Ischaemic preconditioning (IP) is the most effective procedure for endogenous myocardial protection. However, studies on the effects of IP in cardiac surgery are rare and controversial. The present aim was to investigate whether IP improves the haemodynamic recovery of CABG patients. The study inclu...
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Veröffentlicht in: | Scandinavian cardiovascular journal : SCJ 2000-06, Vol.34 (3), p.247-253 |
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creator | WU, Z.-K TARKKA, M. R PEHKONEN, E KAUKINEN, L HONKONEN, E. L KAUKINEN, S |
description | Ischaemic preconditioning (IP) is the most effective procedure for endogenous myocardial protection. However, studies on the effects of IP in cardiac surgery are rare and controversial. The present aim was to investigate whether IP improves the haemodynamic recovery of CABG patients.
The study included 40 stable CABG patients with 3-vessel disease, randomized into an IP group (n = 20) and a control group (n = 20). In the IP group two cycles of 2-min ischaemia following 3-min reperfusion before cross-clamping were induced. The haemodynamics of the patients were followed-up to the first postoperative morning.
The cardiac index decreased at 1 and 6 h after surgery in the control group but increased in the IP group (-0.33 vs 0.09 l/min/m2, p = 0.02 and -0.15 vs 0.57 l/min/m2, p = 0.001, respectively). Depressions in the left ventricular stroke work index and the right ventricular stroke work index at 6 h after surgery were more severe in controls and were statistically significant (p = 0.049 and 0.007, respectively). Less inotropic support was used in the IP group. There were no differences in serum CK-MB, cardiac troponin I, myoglobin or lactate values between the two groups.
IP has a beneficial effect on left ventricular haemodynamic recovery after a CABG operation. |
doi_str_mv | 10.1080/713783110 |
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The study included 40 stable CABG patients with 3-vessel disease, randomized into an IP group (n = 20) and a control group (n = 20). In the IP group two cycles of 2-min ischaemia following 3-min reperfusion before cross-clamping were induced. The haemodynamics of the patients were followed-up to the first postoperative morning.
The cardiac index decreased at 1 and 6 h after surgery in the control group but increased in the IP group (-0.33 vs 0.09 l/min/m2, p = 0.02 and -0.15 vs 0.57 l/min/m2, p = 0.001, respectively). Depressions in the left ventricular stroke work index and the right ventricular stroke work index at 6 h after surgery were more severe in controls and were statistically significant (p = 0.049 and 0.007, respectively). Less inotropic support was used in the IP group. There were no differences in serum CK-MB, cardiac troponin I, myoglobin or lactate values between the two groups.
IP has a beneficial effect on left ventricular haemodynamic recovery after a CABG operation.</description><identifier>ISSN: 1401-7431</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.1080/713783110</identifier><identifier>PMID: 10935770</identifier><language>eng</language><publisher>Copenhagen: Scandinavian University Press</publisher><subject>Aged ; Biological and medical sciences ; Coronary Artery Bypass ; Female ; Hemodynamics - physiology ; Humans ; Ischemic Preconditioning, Myocardial ; Male ; Medical sciences ; Middle Aged ; Postoperative Complications - diagnosis ; Postoperative Complications - physiopathology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Treatment Outcome ; Ventricular Dysfunction - diagnosis ; Ventricular Dysfunction - physiopathology ; Ventricular Function, Left - physiology</subject><ispartof>Scandinavian cardiovascular journal : SCJ, 2000-06, Vol.34 (3), p.247-253</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-81bad1ecb662a123ab52dd1d86e98008d9999e3cf82517d49519dd40989728183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1477833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10935770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WU, Z.-K</creatorcontrib><creatorcontrib>TARKKA, M. R</creatorcontrib><creatorcontrib>PEHKONEN, E</creatorcontrib><creatorcontrib>KAUKINEN, L</creatorcontrib><creatorcontrib>HONKONEN, E. L</creatorcontrib><creatorcontrib>KAUKINEN, S</creatorcontrib><title>Ischaemic preconditioning has a beneficial effect on left ventricular haemodynamic function after a coronary artery biopass grafting operation</title><title>Scandinavian cardiovascular journal : SCJ</title><addtitle>Scand Cardiovasc J</addtitle><description>Ischaemic preconditioning (IP) is the most effective procedure for endogenous myocardial protection. However, studies on the effects of IP in cardiac surgery are rare and controversial. The present aim was to investigate whether IP improves the haemodynamic recovery of CABG patients.
The study included 40 stable CABG patients with 3-vessel disease, randomized into an IP group (n = 20) and a control group (n = 20). In the IP group two cycles of 2-min ischaemia following 3-min reperfusion before cross-clamping were induced. The haemodynamics of the patients were followed-up to the first postoperative morning.
The cardiac index decreased at 1 and 6 h after surgery in the control group but increased in the IP group (-0.33 vs 0.09 l/min/m2, p = 0.02 and -0.15 vs 0.57 l/min/m2, p = 0.001, respectively). Depressions in the left ventricular stroke work index and the right ventricular stroke work index at 6 h after surgery were more severe in controls and were statistically significant (p = 0.049 and 0.007, respectively). Less inotropic support was used in the IP group. There were no differences in serum CK-MB, cardiac troponin I, myoglobin or lactate values between the two groups.
IP has a beneficial effect on left ventricular haemodynamic recovery after a CABG operation.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Coronary Artery Bypass</subject><subject>Female</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Ischemic Preconditioning, Myocardial</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - physiopathology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction - diagnosis</subject><subject>Ventricular Dysfunction - physiopathology</subject><subject>Ventricular Function, Left - physiology</subject><issn>1401-7431</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1q3DAURkVoyF-76AsELUqgC6e6lm3JyxKaNhDoJlmba-lqRsUjOZIdmJfoM9dmhjR3o4s4Oh_6GPsM4haEFt8USKUlgDhhF9DUUJRCNB-WvRJQqErCObvM-Y8QUOsaztg5iFbWSokL9vchmy3Szhs-JjIxWD_5GHzY8C1mjrynQM4bjwMn58hMPAY-kJv4K4UpeTMPmPiqiHYfcBW5OZhVwtFNlBaHiSkGTHuOabnY897HEXPmm7QQa1QcKeH65CM7dThk-nQ8r9jz_Y-nu1_F4--fD3ffHwsjQUyFhh4tkOmbpkQoJfZ1aS1Y3VCrhdC2XYakcbqsQdmqraG1thKtblWpQcsrdnPwjim-zJSnbuezoWHAQHHOnQJVKqVW8OsBNCnmnMh1Y_K75S8diG4tv3srf2Gvj9K535F9Rx7aXoAvRwCzwcElDMbn_1y1Jkr5D_W5jb8</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>WU, Z.-K</creator><creator>TARKKA, M. R</creator><creator>PEHKONEN, E</creator><creator>KAUKINEN, L</creator><creator>HONKONEN, E. L</creator><creator>KAUKINEN, S</creator><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Ischaemic preconditioning has a beneficial effect on left ventricular haemodynamic function after a coronary artery biopass grafting operation</title><author>WU, Z.-K ; TARKKA, M. R ; PEHKONEN, E ; KAUKINEN, L ; HONKONEN, E. L ; KAUKINEN, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-81bad1ecb662a123ab52dd1d86e98008d9999e3cf82517d49519dd40989728183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Coronary Artery Bypass</topic><topic>Female</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Ischemic Preconditioning, Myocardial</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - physiopathology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction - diagnosis</topic><topic>Ventricular Dysfunction - physiopathology</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WU, Z.-K</creatorcontrib><creatorcontrib>TARKKA, M. R</creatorcontrib><creatorcontrib>PEHKONEN, E</creatorcontrib><creatorcontrib>KAUKINEN, L</creatorcontrib><creatorcontrib>HONKONEN, E. L</creatorcontrib><creatorcontrib>KAUKINEN, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WU, Z.-K</au><au>TARKKA, M. R</au><au>PEHKONEN, E</au><au>KAUKINEN, L</au><au>HONKONEN, E. L</au><au>KAUKINEN, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischaemic preconditioning has a beneficial effect on left ventricular haemodynamic function after a coronary artery biopass grafting operation</atitle><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle><addtitle>Scand Cardiovasc J</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>34</volume><issue>3</issue><spage>247</spage><epage>253</epage><pages>247-253</pages><issn>1401-7431</issn><eissn>1651-2006</eissn><abstract>Ischaemic preconditioning (IP) is the most effective procedure for endogenous myocardial protection. However, studies on the effects of IP in cardiac surgery are rare and controversial. The present aim was to investigate whether IP improves the haemodynamic recovery of CABG patients.
The study included 40 stable CABG patients with 3-vessel disease, randomized into an IP group (n = 20) and a control group (n = 20). In the IP group two cycles of 2-min ischaemia following 3-min reperfusion before cross-clamping were induced. The haemodynamics of the patients were followed-up to the first postoperative morning.
The cardiac index decreased at 1 and 6 h after surgery in the control group but increased in the IP group (-0.33 vs 0.09 l/min/m2, p = 0.02 and -0.15 vs 0.57 l/min/m2, p = 0.001, respectively). Depressions in the left ventricular stroke work index and the right ventricular stroke work index at 6 h after surgery were more severe in controls and were statistically significant (p = 0.049 and 0.007, respectively). Less inotropic support was used in the IP group. There were no differences in serum CK-MB, cardiac troponin I, myoglobin or lactate values between the two groups.
IP has a beneficial effect on left ventricular haemodynamic recovery after a CABG operation.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Scandinavian University Press</pub><pmid>10935770</pmid><doi>10.1080/713783110</doi><tpages>7</tpages></addata></record> |
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subjects | Aged Biological and medical sciences Coronary Artery Bypass Female Hemodynamics - physiology Humans Ischemic Preconditioning, Myocardial Male Medical sciences Middle Aged Postoperative Complications - diagnosis Postoperative Complications - physiopathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Treatment Outcome Ventricular Dysfunction - diagnosis Ventricular Dysfunction - physiopathology Ventricular Function, Left - physiology |
title | Ischaemic preconditioning has a beneficial effect on left ventricular haemodynamic function after a coronary artery biopass grafting operation |
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