Inhibitory Mechanism of Store-operated Ca2+ Channels by Zinc

Capacitative calcium influx plays an important role in shaping the Ca2+ response of various tissues and cell types. Inhibition by heavy metals is a hallmark of store-operated calcium channel (SOCC) activity. Paradoxically, although zinc is the only potentially physiological relevant ion, it is the l...

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Veröffentlicht in:	The Journal of biological chemistry 2004-03, Vol.279 (12), p.11106-11111
Hauptverfasser:	Gore, Ariel, Moran, Arie, Hershfinkel, Michal, Sekler, Israel
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - drug effects Calcium Channels - metabolism Cell Line Humans Oxidation-Reduction Zinc - pharmacology
Online-Zugang:	Volltext
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