SUMO: a regulator of gene expression and genome integrity
Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of...
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| Veröffentlicht in: | Oncogene 2004-03, Vol.23 (11), p.1998-2008 |
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| container_title | Oncogene |
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| creator | Müller, Stefan Ledl, Andreas Schmidt, Darja |
| description | Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of downstream transcription factors in these pathways presumably by facilitating the recruitment of corepressors or mediating the assembly of repressor complexes. Additionally, evidence is accumulating that SUMO controls pathways important for the surveillance of genome integrity. SUMO regulates the PML/p53 tumour suppressor network, a key determinant in the cellular response to DNA damage. Moreover, proteins that maintain genomic stability by functioning at the interface between DNA replication, recombination and repair processes undergo SUMOylation. We will discuss some key findings that exemplify the role of SUMO in transcriptional regulation and genome surveillance. |
| doi_str_mv | 10.1038/sj.onc.1207415 |
| format | Article |
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The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of downstream transcription factors in these pathways presumably by facilitating the recruitment of corepressors or mediating the assembly of repressor complexes. Additionally, evidence is accumulating that SUMO controls pathways important for the surveillance of genome integrity. SUMO regulates the PML/p53 tumour suppressor network, a key determinant in the cellular response to DNA damage. Moreover, proteins that maintain genomic stability by functioning at the interface between DNA replication, recombination and repair processes undergo SUMOylation. 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The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of downstream transcription factors in these pathways presumably by facilitating the recruitment of corepressors or mediating the assembly of repressor complexes. Additionally, evidence is accumulating that SUMO controls pathways important for the surveillance of genome integrity. SUMO regulates the PML/p53 tumour suppressor network, a key determinant in the cellular response to DNA damage. Moreover, proteins that maintain genomic stability by functioning at the interface between DNA replication, recombination and repair processes undergo SUMOylation. 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genetics</subject><subject>SUMO-1 Protein - metabolism</subject><subject>Surveillance</subject><subject>Transcription factors</subject><subject>Transcription, Genetic</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><subject>Ubiquitin</subject><subject>Wnt protein</subject><subject>Yeast</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0U2LFDEQBuAgijuuXj1Ko-CtZ1P5jrdl8QtW9qB7Dpl0ddNDdzIm3eD-e7PMwICwSA6BylNFhZeQt0C3QLm5KvttimELjGoB8hnZgNCqldKK52RDraStZZxdkFel7Cml2lL2klyApAyM0Rtif97_uPvU-CbjsE5-SblJfTNgxAb_HDKWMqbY-Ng91tKMzRgXHPK4PLwmL3o_FXxzui_J_ZfPv26-tbd3X7_fXN-2QTK2tHzXUU6997IHpAF723OluPCBdj6ARhNYz4TQfGcxoOXCMqqMYdAZkKj5Jfl4nHvI6feKZXHzWAJOk4-Y1uI0aKbBqv9C0FYKLniFH_6B-7TmWD_hmBLAhRLSVPX-ScU0l0oqW9H2iAY_oRtjn5bsQz0dzmNIEfux1q_BWFDKKnFuCDmVkrF3hzzOPj84oO4xUVf2ribqTonWhnenNdbdjN2ZnyKs4OoISn2KA-bznk-M_AuRJalv</recordid><startdate>20040315</startdate><enddate>20040315</enddate><creator>Müller, Stefan</creator><creator>Ledl, Andreas</creator><creator>Schmidt, Darja</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040315</creationdate><title>SUMO: a regulator of gene expression and genome integrity</title><author>Müller, Stefan ; Ledl, Andreas ; Schmidt, Darja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-3bd030aaa5f1e0cef9f36634ac0dac17e8c2f24473b9ece93492068821d815e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cell Biology</topic><topic>Cytokines</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA biosynthesis</topic><topic>DNA damage</topic><topic>DNA repair</topic><topic>Enzymes</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Gene regulation</topic><topic>Genome</topic><topic>Genomes</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Biological</topic><topic>Oncology</topic><topic>p53 Protein</topic><topic>Post-translation</topic><topic>Protein Processing, Post-Translational</topic><topic>Proteins</topic><topic>Recombination</topic><topic>review</topic><topic>Signal transduction</topic><topic>SUMO protein</topic><topic>SUMO-1 Protein - genetics</topic><topic>SUMO-1 Protein - metabolism</topic><topic>Surveillance</topic><topic>Transcription factors</topic><topic>Transcription, Genetic</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><topic>Ubiquitin</topic><topic>Wnt protein</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müller, Stefan</creatorcontrib><creatorcontrib>Ledl, Andreas</creatorcontrib><creatorcontrib>Schmidt, Darja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller, Stefan</au><au>Ledl, Andreas</au><au>Schmidt, Darja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SUMO: a regulator of gene expression and genome integrity</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2004-03-15</date><risdate>2004</risdate><volume>23</volume><issue>11</issue><spage>1998</spage><epage>2008</epage><pages>1998-2008</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity of downstream transcription factors in these pathways presumably by facilitating the recruitment of corepressors or mediating the assembly of repressor complexes. Additionally, evidence is accumulating that SUMO controls pathways important for the surveillance of genome integrity. SUMO regulates the PML/p53 tumour suppressor network, a key determinant in the cellular response to DNA damage. Moreover, proteins that maintain genomic stability by functioning at the interface between DNA replication, recombination and repair processes undergo SUMOylation. We will discuss some key findings that exemplify the role of SUMO in transcriptional regulation and genome surveillance.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15021887</pmid><doi>10.1038/sj.onc.1207415</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; SpringerNature Complete Journals |
| subjects | Animals Apoptosis Cell Biology Cytokines Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA repair Enzymes Gene expression Gene Expression Regulation Gene regulation Genome Genomes Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Models, Biological Oncology p53 Protein Post-translation Protein Processing, Post-Translational Proteins Recombination review Signal transduction SUMO protein SUMO-1 Protein - genetics SUMO-1 Protein - metabolism Surveillance Transcription factors Transcription, Genetic Tumor suppressor genes Tumors Ubiquitin Wnt protein Yeast |
| title | SUMO: a regulator of gene expression and genome integrity |
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