Prevention of Fas-mediated hepatic failure by transferrin

Recent studies in lymphohemopoietic cells show that transferrin (Tf), a pivotal component of iron transport and metabolism, also exerts cytoprotective functions. We show here in a murine model that Tf interferes with Fas-mediated hepatocyte death and liver failure. The mechanism involves the downreg...

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Veröffentlicht in:	Laboratory investigation 2004-03, Vol.84 (3), p.342-352
Hauptverfasser:	Lesnikov, Vladimir A, Lesnikova, Marina P, Shulman, Howard M, Wilson, Heather-Marie, Hockenbery, David M, Kocher, Markus, Pierpaoli, Walter, Deeg, H Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology apoptosis Apoptosis - drug effects bcl-X Protein BH3 Interacting Domain Death Agonist Protein Biological and medical sciences Biotechnology Carrier Proteins - metabolism Caspase 3 Caspase 9 Caspases - metabolism Cell Line Cytochromes c - metabolism Cytoprotection Enzyme Activation - drug effects fas Receptor - physiology fas signaling Female Fundamental and applied biological sciences. Psychology hepatocytes Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Iron - metabolism Laboratory Medicine Liver Failure - etiology Liver Failure - pathology Liver Failure - physiopathology Liver Failure - prevention & control Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Inbred C57BL Pathology Proto-Oncogene Proteins c-bcl-2 - metabolism research-article Signal Transduction - drug effects transferrin Transferrin - pharmacology
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