Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl
We report a pharmacokinetic study in a 6-year-old girl with congenital human immunodeficiency virus type 1 and cytomegalovirus coinfection maintained on iv ganciclovir for 6 years. Increasing infection and thrombosis caused by her iv device necessitated alternative therapy. Single dose pharmacokinet...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2004-03, Vol.23 (3), p.263-266 |
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| container_end_page | 266 |
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| container_issue | 3 |
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| container_title | The Pediatric infectious disease journal |
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| creator | BURRI, MARCUS WILTSHIRE, HUGH KAHLERT, CHRISTIAN WOUTERS, GEORGE RUDIN, CHRISTOPH |
| description | We report a pharmacokinetic study in a 6-year-old girl with congenital human immunodeficiency virus type 1 and cytomegalovirus coinfection maintained on iv ganciclovir for 6 years. Increasing infection and thrombosis caused by her iv device necessitated alternative therapy. Single dose pharmacokinetics of ganciclovir 4.4 mg/kg iv and valganciclovir 13.2 and 26.3 mg/kg po were studied with high performance liquid chromatography/tandem mass spectrometry. The two oral dosages yielded areas under the concentration curve of 14.3 and 28.7 μg·h/ml, equivalent to 43% bioavailability of ganciclovir from valganciclovir, which exceeded the area under the concentration curve of 11.1 μg·h/ml yielded by ganciclovir 4.4 mg/kg iv. Oral valganciclovir achieved therapeutic and dosage-proportional plasma concentrations in the child we studied. |
| doi_str_mv | 10.1097/01.inf.0000116760.16582.a9 |
| format | Article |
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Increasing infection and thrombosis caused by her iv device necessitated alternative therapy. Single dose pharmacokinetics of ganciclovir 4.4 mg/kg iv and valganciclovir 13.2 and 26.3 mg/kg po were studied with high performance liquid chromatography/tandem mass spectrometry. The two oral dosages yielded areas under the concentration curve of 14.3 and 28.7 μg·h/ml, equivalent to 43% bioavailability of ganciclovir from valganciclovir, which exceeded the area under the concentration curve of 11.1 μg·h/ml yielded by ganciclovir 4.4 mg/kg iv. Oral valganciclovir achieved therapeutic and dosage-proportional plasma concentrations in the child we studied.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/01.inf.0000116760.16582.a9</identifier><identifier>PMID: 15014306</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Administration, Oral ; AIDS-Related Opportunistic Infections - drug therapy ; Antiviral Agents - pharmacokinetics ; Antiviral Agents - therapeutic use ; Area Under Curve ; Biological and medical sciences ; Biological Availability ; Child ; Chromatography, High Pressure Liquid ; Cytomegalovirus Infections - drug therapy ; Female ; Fundamental and applied biological sciences. 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Increasing infection and thrombosis caused by her iv device necessitated alternative therapy. Single dose pharmacokinetics of ganciclovir 4.4 mg/kg iv and valganciclovir 13.2 and 26.3 mg/kg po were studied with high performance liquid chromatography/tandem mass spectrometry. The two oral dosages yielded areas under the concentration curve of 14.3 and 28.7 μg·h/ml, equivalent to 43% bioavailability of ganciclovir from valganciclovir, which exceeded the area under the concentration curve of 11.1 μg·h/ml yielded by ganciclovir 4.4 mg/kg iv. Oral valganciclovir achieved therapeutic and dosage-proportional plasma concentrations in the child we studied.</description><subject>Administration, Oral</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>Antiviral Agents - pharmacokinetics</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Child</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cytomegalovirus Infections - drug therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganciclovir - analogs & derivatives</subject><subject>Ganciclovir - pharmacokinetics</subject><subject>Ganciclovir - therapeutic use</subject><subject>General aspects</subject><subject>Humans</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Valganciclovir</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkN1qGzEQRkVpady0r1CWQnsnd0bS6id3JbRNIZCb9FqMtbKtRt51JTtp3r5ybEgEg9DHGQ1zGPuEMEdw5ivgPI3LObSDqI1use6tmJN7xWbYS8HBWfOazcA65FJre8be1fqn8VIhvGVn2AMqCXrGbm8K5e6e8orGkEKe7lPp0tiFdcpDieNFV9O4yrEbphq77ZrKhsJ0l8a4S6EeSGrEP_4YqfApD90qlfyevVlSrvHD6T5nv398v7284tc3P39dfrvmQToAbq1UDi0a4yKgNXIQOrbI6bZlDwvhbHSRpLP9oBQZdEBkQKhFS0CTPGdfjv9uy_R3H-vOb1INMWca47Sv3qARWqJt4MURDGWqtcSl35a0ofLoEfzBqQf0zal_duqfnHpyrfnjacp-sYnDc-tJYgM-nwCqgfKyHFTWF5wWPbq-cerIPUx5F0u9y_uHWPw6Ut6tn0Zr1SsuABTI9uKtBMj_Wk2OEQ</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>BURRI, MARCUS</creator><creator>WILTSHIRE, HUGH</creator><creator>KAHLERT, CHRISTIAN</creator><creator>WOUTERS, GEORGE</creator><creator>RUDIN, CHRISTOPH</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl</title><author>BURRI, MARCUS ; WILTSHIRE, HUGH ; KAHLERT, CHRISTIAN ; WOUTERS, GEORGE ; RUDIN, CHRISTOPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3900-88349181779e01873d26e3499609750b298e9ea3985d44a7190aa7024b98506a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Oral</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>Antiviral Agents - pharmacokinetics</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Child</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cytomegalovirus Infections - drug therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Increasing infection and thrombosis caused by her iv device necessitated alternative therapy. Single dose pharmacokinetics of ganciclovir 4.4 mg/kg iv and valganciclovir 13.2 and 26.3 mg/kg po were studied with high performance liquid chromatography/tandem mass spectrometry. The two oral dosages yielded areas under the concentration curve of 14.3 and 28.7 μg·h/ml, equivalent to 43% bioavailability of ganciclovir from valganciclovir, which exceeded the area under the concentration curve of 11.1 μg·h/ml yielded by ganciclovir 4.4 mg/kg iv. Oral valganciclovir achieved therapeutic and dosage-proportional plasma concentrations in the child we studied.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15014306</pmid><doi>10.1097/01.inf.0000116760.16582.a9</doi><tpages>4</tpages></addata></record> |
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| subjects | Administration, Oral AIDS-Related Opportunistic Infections - drug therapy Antiviral Agents - pharmacokinetics Antiviral Agents - therapeutic use Area Under Curve Biological and medical sciences Biological Availability Child Chromatography, High Pressure Liquid Cytomegalovirus Infections - drug therapy Female Fundamental and applied biological sciences. Psychology Ganciclovir - analogs & derivatives Ganciclovir - pharmacokinetics Ganciclovir - therapeutic use General aspects Humans Mass Spectrometry Medical sciences Microbiology Valganciclovir |
| title | Oral valganciclovir in children: single dose pharmacokinetics in a six-year-old girl |
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