Effect of sildenafil citrate (Viagra) on retinal blood vessel diameter
PURPOSE: The present investigation was conducted to evaluate the effect of sildenafil citrate (Viagra, Pfizer Inc., New York, NY) on retinal blood vessel diameter. DESIGN: Double-blind randomized, placebo-controlled, cross-over study. METHODS: Fifteen healthy male volunteers (mean age 39 years) rece...
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| Veröffentlicht in: | American journal of ophthalmology 2002-06, Vol.133 (6), p.809-812 |
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| creator | Grunwald, Juan E. Metelitsina, Tatyana Grunwald, Lili |
| description | PURPOSE: The present investigation was conducted to evaluate the effect of sildenafil citrate (Viagra, Pfizer Inc., New York, NY) on retinal blood vessel diameter.
DESIGN: Double-blind randomized, placebo-controlled, cross-over study.
METHODS: Fifteen healthy male volunteers (mean age 39 years) received 100-mg doses of sildenafil or matching placebo on 2 separate days. Monochromatic fundus photography was obtained in one eye, and brachial artery blood pressure and intraocular pressure were measured at baseline, 1 hour, and 5 hours after dosing. The diameters of two major temporal veins and one artery were measured in a masked fashion from digitized photographic negatives.
RESULTS: In comparison with placebo, no statistically significant change in average venous diameter was observed for the superior (analysis of variance [ANOVA],
P = .97), inferior retinal temporal vein (ANOVA,
P = .73), or the retinal temporal artery (ANOVA,
P = .89) after sildenafil treatment. In comparison to placebo, there was no significant difference in the percentage change from baseline in venous or arterial diameter at 1 or 5 hours after sildenafil. The power to detect a 6.5% change in retinal vascular diameter following sildenafil was approximately 80% (
P = .05).
CONCLUSIONS: These data suggest that at the maximum therapeutic dose used clinically (100 mg), sildenafil does not have a significant effect on retinal vascular caliber. |
| doi_str_mv | 10.1016/S0002-9394(02)01391-0 |
| format | Article |
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DESIGN: Double-blind randomized, placebo-controlled, cross-over study.
METHODS: Fifteen healthy male volunteers (mean age 39 years) received 100-mg doses of sildenafil or matching placebo on 2 separate days. Monochromatic fundus photography was obtained in one eye, and brachial artery blood pressure and intraocular pressure were measured at baseline, 1 hour, and 5 hours after dosing. The diameters of two major temporal veins and one artery were measured in a masked fashion from digitized photographic negatives.
RESULTS: In comparison with placebo, no statistically significant change in average venous diameter was observed for the superior (analysis of variance [ANOVA],
P = .97), inferior retinal temporal vein (ANOVA,
P = .73), or the retinal temporal artery (ANOVA,
P = .89) after sildenafil treatment. In comparison to placebo, there was no significant difference in the percentage change from baseline in venous or arterial diameter at 1 or 5 hours after sildenafil. The power to detect a 6.5% change in retinal vascular diameter following sildenafil was approximately 80% (
P = .05).
CONCLUSIONS: These data suggest that at the maximum therapeutic dose used clinically (100 mg), sildenafil does not have a significant effect on retinal vascular caliber.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(02)01391-0</identifier><identifier>PMID: 12036673</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors ; Adult ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Blood Pressure - drug effects ; Cardiovascular system ; Cross-Over Studies ; Double-Blind Method ; Humans ; Image Processing, Computer-Assisted ; Intraocular Pressure - drug effects ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Phosphodiesterase Inhibitors - pharmacology ; Photography ; Piperazines - pharmacology ; Purines ; Regional Blood Flow ; Retinal Vessels - drug effects ; Sildenafil Citrate ; Sulfones ; Vasodilation ; Vasodilator Agents - pharmacology ; Vasodilator agents. Cerebral vasodilators</subject><ispartof>American journal of ophthalmology, 2002-06, Vol.133 (6), p.809-812</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-683355fb9c9b7ec797b317103d8fad2fcce04d337612db5d18f6ae2d1cd282ce3</citedby><cites>FETCH-LOGICAL-c391t-683355fb9c9b7ec797b317103d8fad2fcce04d337612db5d18f6ae2d1cd282ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9394(02)01391-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13709070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12036673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grunwald, Juan E.</creatorcontrib><creatorcontrib>Metelitsina, Tatyana</creatorcontrib><creatorcontrib>Grunwald, Lili</creatorcontrib><title>Effect of sildenafil citrate (Viagra) on retinal blood vessel diameter</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>PURPOSE: The present investigation was conducted to evaluate the effect of sildenafil citrate (Viagra, Pfizer Inc., New York, NY) on retinal blood vessel diameter.
DESIGN: Double-blind randomized, placebo-controlled, cross-over study.
METHODS: Fifteen healthy male volunteers (mean age 39 years) received 100-mg doses of sildenafil or matching placebo on 2 separate days. Monochromatic fundus photography was obtained in one eye, and brachial artery blood pressure and intraocular pressure were measured at baseline, 1 hour, and 5 hours after dosing. The diameters of two major temporal veins and one artery were measured in a masked fashion from digitized photographic negatives.
RESULTS: In comparison with placebo, no statistically significant change in average venous diameter was observed for the superior (analysis of variance [ANOVA],
P = .97), inferior retinal temporal vein (ANOVA,
P = .73), or the retinal temporal artery (ANOVA,
P = .89) after sildenafil treatment. In comparison to placebo, there was no significant difference in the percentage change from baseline in venous or arterial diameter at 1 or 5 hours after sildenafil. The power to detect a 6.5% change in retinal vascular diameter following sildenafil was approximately 80% (
P = .05).
CONCLUSIONS: These data suggest that at the maximum therapeutic dose used clinically (100 mg), sildenafil does not have a significant effect on retinal vascular caliber.</description><subject>3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Intraocular Pressure - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Photography</subject><subject>Piperazines - pharmacology</subject><subject>Purines</subject><subject>Regional Blood Flow</subject><subject>Retinal Vessels - drug effects</subject><subject>Sildenafil Citrate</subject><subject>Sulfones</subject><subject>Vasodilation</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotlYfQclGaRejuXQmk5VIaVUouPCyDZnkRCLpTE2mBd_e6QW7dPVz4Dvn_HwIXVJySwkt7l4JISyTXI6HhI0I5ZJm5Aj1aSlkRktJj1H_D-mhs5S-urEQY3GKepQRXhSC99Fs6hyYFjcOJx8s1Nr5gI1vo24BDz-8_ox6hJsaR2h9rQOuQtNYvIaUIGDr9QJaiOfoxOmQ4GKfA_Q-m75NnrL5y-Pz5GGema5fmxUl53nuKmlkJcAIKSpOBSXclk5b5owBMraci4IyW-WWlq7QwCw1lpXMAB-gm93dZWy-V5BatfDJQAi6hmaVlKCC5WUuOjDfgSY2KUVwahn9QscfRYnaCFRbgWpjR3W5FahIt3e1f7CqFmAPW3tjHXC9B3QyOrioa-PTgeOCSCI2h-53HHQ61h6iSsZDbcD62AlXtvH_VPkFJ-mMKg</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Grunwald, Juan E.</creator><creator>Metelitsina, Tatyana</creator><creator>Grunwald, Lili</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Effect of sildenafil citrate (Viagra) on retinal blood vessel diameter</title><author>Grunwald, Juan E. ; Metelitsina, Tatyana ; Grunwald, Lili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-683355fb9c9b7ec797b317103d8fad2fcce04d337612db5d18f6ae2d1cd282ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Intraocular Pressure - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Photography</topic><topic>Piperazines - pharmacology</topic><topic>Purines</topic><topic>Regional Blood Flow</topic><topic>Retinal Vessels - drug effects</topic><topic>Sildenafil Citrate</topic><topic>Sulfones</topic><topic>Vasodilation</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grunwald, Juan E.</creatorcontrib><creatorcontrib>Metelitsina, Tatyana</creatorcontrib><creatorcontrib>Grunwald, Lili</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grunwald, Juan E.</au><au>Metelitsina, Tatyana</au><au>Grunwald, Lili</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of sildenafil citrate (Viagra) on retinal blood vessel diameter</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>133</volume><issue>6</issue><spage>809</spage><epage>812</epage><pages>809-812</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>PURPOSE: The present investigation was conducted to evaluate the effect of sildenafil citrate (Viagra, Pfizer Inc., New York, NY) on retinal blood vessel diameter.
DESIGN: Double-blind randomized, placebo-controlled, cross-over study.
METHODS: Fifteen healthy male volunteers (mean age 39 years) received 100-mg doses of sildenafil or matching placebo on 2 separate days. Monochromatic fundus photography was obtained in one eye, and brachial artery blood pressure and intraocular pressure were measured at baseline, 1 hour, and 5 hours after dosing. The diameters of two major temporal veins and one artery were measured in a masked fashion from digitized photographic negatives.
RESULTS: In comparison with placebo, no statistically significant change in average venous diameter was observed for the superior (analysis of variance [ANOVA],
P = .97), inferior retinal temporal vein (ANOVA,
P = .73), or the retinal temporal artery (ANOVA,
P = .89) after sildenafil treatment. In comparison to placebo, there was no significant difference in the percentage change from baseline in venous or arterial diameter at 1 or 5 hours after sildenafil. The power to detect a 6.5% change in retinal vascular diameter following sildenafil was approximately 80% (
P = .05).
CONCLUSIONS: These data suggest that at the maximum therapeutic dose used clinically (100 mg), sildenafil does not have a significant effect on retinal vascular caliber.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12036673</pmid><doi>10.1016/S0002-9394(02)01391-0</doi><tpages>4</tpages></addata></record> |
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| subjects | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors Adult Biological and medical sciences Blood Flow Velocity - drug effects Blood Pressure - drug effects Cardiovascular system Cross-Over Studies Double-Blind Method Humans Image Processing, Computer-Assisted Intraocular Pressure - drug effects Male Medical sciences Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Photography Piperazines - pharmacology Purines Regional Blood Flow Retinal Vessels - drug effects Sildenafil Citrate Sulfones Vasodilation Vasodilator Agents - pharmacology Vasodilator agents. Cerebral vasodilators |
| title | Effect of sildenafil citrate (Viagra) on retinal blood vessel diameter |
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