Modelling haematopoietic malignancies in the mouse and therapeutical implications

Modelling human disease in the mouse has become an essential activity in biomedical research in order to unravel molecular mechanisms underlying pathological conditions as well as to determine in vivo the consequences of aberrant gene function. The mouse is by far the most accessible mammalian syste...

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Veröffentlicht in:	Oncogene 2002-05, Vol.21 (21), p.3445-3458
Hauptverfasser:	Bernardi, Rosa, Grisendi, Silvia, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibiotics Blood cancer Cancer Chromosomes Disease Models, Animal Fusion Proteins, bcr-abl - genetics Genes Genetic engineering Genomes Hematologic Neoplasms - genetics Hematologic Neoplasms - metabolism Hematological diseases Hematology Humans Leukemia Leukemia - genetics Leukemia, Promyelocytic, Acute - genetics Lymphoma Lymphoma - genetics Medical research Mice Mice, Transgenic Models, Biological Molecular modelling Tetracycline - pharmacology Zebrafish
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