Genetic alterations in early‐stage pulmonary large cell neuroendocrine carcinoma

BACKGROUND Small cell lung carcinoma (SCLC) and pulmonary large cell neuroendocrine carcinoma (LCNEC) are high‐grade malignant neuroendocrine tumors. Histologic differentiation between SCLC and LCNEC is difficult in some cases and to the authors' knowledge, genetic alterations associated with L...

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Veröffentlicht in:	Cancer 2004-03, Vol.100 (6), p.1190-1198
Hauptverfasser:	Hiroshima, Kenzo, Iyoda, Akira, Shibuya, Kiyoshi, Haga, Yukiko, Toyozaki, Tetsuya, Iizasa, Toshihiko, Nakayama, Toshinori, Fujisawa, Takehiko, Ohwada, Hidemi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Large Cell - genetics Carcinoma, Large Cell - mortality Carcinoma, Neuroendocrine - genetics Carcinoma, Neuroendocrine - mortality Carcinoma, Small Cell - genetics Carcinoma, Small Cell - mortality Diagnosis, Differential DNA Methylation Genes, p16 - physiology Humans Immunohistochemistry large cell neuroendocrine carcinoma Loss of Heterozygosity lung Lung Neoplasms - genetics Medical sciences methylation Neoplasm Staging p16 p53 Polymerase Chain Reaction retinoblastoma protein Retinoblastoma Protein - biosynthesis small cell carcinoma Tumor Suppressor Protein p53 - biosynthesis Tumors
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