Determination of lormetazepam and its main metabolite in serum using micellar electrokinetic capillary chromatography with direct injection and ultraviolet absorbance detection

The use of micellar electrokinetic chromatography for the determination of lormetazepam and its metabolite, lorazepam, in serum samples at a concentration range of therapeutic interest was investigated. The separation was carried out at 30 °C and 25 kV, using a 15 m M borate–phosphate buffer (pH 8)...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2002-06, Vol.773 (2), p.151-158
Hauptverfasser:	Berzas Nevado, J.J., Castañeda Peñalvo, G., Pinilla Calderón, M.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Anxiety Agents - blood Benzodiazepines Buffers Chromatography, Micellar Electrokinetic Capillary - methods Humans Hydrogen-Ion Concentration Lorazepam Lorazepam - analogs & derivatives Lorazepam - blood Lormetazepam Sensitivity and Specificity Surface-Active Agents
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