Isolation and Identification of the Major Heparan Sulfate Proteoglycans in the Developing Bovine Rib Growth Plate

Heparan sulfate proteoglycans are thought to mediate the action of growth factors. The heparan sulfate-containing proteoglycans in extracts of the bovine fetal rib growth plate were detected using the monoclonal antibody 3G10, which recognizes a neoepitope generated by heparitinase digestion (David,...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (22), p.19461-19469
Hauptverfasser:	Govindraj, Prasanthi, West, Leigh, Koob, Thomas J., Neame, Peter, Doege, Kurt, Hassell, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	aggrecan Amino Acid Sequence Animals Blotting, Western Cattle Cesium - pharmacology Chlorides - pharmacology Chondroitin Sulfates - chemistry Chromatography, Ion Exchange Epitopes heparan sulfate Heparan Sulfate Proteoglycans - chemistry Kidney - metabolism Molecular Sequence Data Peptides - chemistry perlecan Protein Binding Protein Structure, Tertiary Proteoglycans - metabolism Ribs - embryology Sequence Homology, Amino Acid Time Factors Trypsin - pharmacology
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