Identification and in Vitro Biological Activities of Hop Proanthocyanidins: Inhibition of nNOS Activity and Scavenging of Reactive Nitrogen Species

Oligomeric proanthocyanidins constitute a group of water-soluble polyphenolic tannins that are present in the female inflorescences (up to 5% dry wt) of the hop plant (Humulus lupulus). Humans are exposed to hop proanthocyanidins through consumption of beer. Proanthocyanidins from hops were characte...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2002-06, Vol.50 (12), p.3435-3443
Hauptverfasser:	Stevens, Jan F, Miranda, Cristobal L, Wolthers, Kirsten R, Schimerlik, Michael, Deinzer, Max L, Buhler, Donald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Anthocyanins - analysis Anthocyanins - chemistry Anthocyanins - pharmacology Antioxidants - pharmacology Aromatic and heterocyclic compounds Biflavonoids Biological and medical sciences Catechin Dimerization Enzyme Inhibitors - pharmacology Free Radical Scavengers Fundamental and applied biological sciences. Psychology Heterocyclic compounds, pigments Humulus - chemistry Lipid Peroxidation - drug effects Lipoproteins, LDL - chemistry Molecular Structure Molsidomine - analogs & derivatives Molsidomine - pharmacology Nitric Oxide - chemistry Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type I Other biological molecules Proanthocyanidins Spectrometry, Mass, Electrospray Ionization Thiobarbituric Acid Reactive Substances - analysis
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