Analysis of APAF-1 expression in human cutaneous melanoma progression

: APAF‐1 plays a pivotal role in mitochondria‐dependent apoptosis, binding to cytochrome c and favoring activation of caspase‐9. It has been shown that epigenetic silencing of the APAF‐1 gene is a common event in several metastatic melanoma cells in vitro. We determined, by Western blot, variation i...

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Veröffentlicht in:	Experimental dermatology 2004-02, Vol.13 (2), p.93-97
Hauptverfasser:	Baldi, Alfonso, Santini, Daniele, Russo, Patrizia, Catricalà, Caterina, Amantea, Ada, Picardo, Mauro, Tatangelo, Fabiana, Botti, Gerardo, Dragonetti, Emanuele, Murace, Raffaele, Tonini, Giuseppe, Natali, Pier Giorgio, Baldi, Feliciano, Paggi, Marco G.
Format:	Artikel
Sprache:	eng
Schlagworte:	APAF-1 Apoptosis - genetics Apoptotic Protease-Activating Factor 1 Biological and medical sciences Biopsy Cell Line, Tumor Dermatology Humans Immunohistochemistry Medical sciences melanoma Melanoma - genetics Melanoma - pathology Mitochondria - genetics Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Predictive Value of Tests Proteins - genetics Retrospective Studies Skin Neoplasms - genetics Skin Neoplasms - pathology Tumor Cells, Cultured tumor progression Tumors of the skin and soft tissue. Premalignant lesions
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