Determination of an Ensemble of Structures Representing the Denatured State of the Bovine Acyl-Coenzyme A Binding Protein

The denatured state of a protein contains important information about the determinants of the folding process. By combining site-directed spin-labeling NMR experiments and restrained computer simulations, we have determined ensembles of conformations that represent the denatured state of the bovine...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-03, Vol.126 (10), p.3291-3299
Hauptverfasser:	Lindorff-Larsen, Kresten, Kristjansdottir, Sigridur, Teilum, Kaare, Fieber, Wolfgang, Dobson, Christopher M, Poulsen, Flemming M, Vendruscolo, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemistry Acyl Coenzyme A - metabolism Animals Biological and medical sciences Carrier Proteins - chemistry Carrier Proteins - metabolism Cattle Computer Simulation Conformational dynamics in molecular biology Fundamental and applied biological sciences. Psychology Guanidine - chemistry Kinetics Models, Molecular Molecular biophysics Monte Carlo Method Nuclear Magnetic Resonance, Biomolecular Protein Conformation Protein Denaturation Spin Labels
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