Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood

Children surviving treatment for malignant brain tumors commonly have problems maintaining their premorbid levels of intellectual development and academic achievement. Our group has been especially interested in the effects of treatment on normal appearing white matter (NAWM) on MRI and the influenc...

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Veröffentlicht in:Journal of the International Neuropsychological Society 2004-03, Vol.10 (2), p.180-189
Hauptverfasser: MULHERN, RAYMOND K., WHITE, HOLLY A., GLASS, JOHN O., KUN, LARRY E., LEIGH, LAURIE, THOMPSON, STEPHEN J., REDDICK, WILBURN E.
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container_end_page 189
container_issue 2
container_start_page 180
container_title Journal of the International Neuropsychological Society
container_volume 10
creator MULHERN, RAYMOND K.
WHITE, HOLLY A.
GLASS, JOHN O.
KUN, LARRY E.
LEIGH, LAURIE
THOMPSON, STEPHEN J.
REDDICK, WILBURN E.
description Children surviving treatment for malignant brain tumors commonly have problems maintaining their premorbid levels of intellectual development and academic achievement. Our group has been especially interested in the effects of treatment on normal appearing white matter (NAWM) on MRI and the influence of NAWM volumes on neurocognitive functioning. The present study assessed NAWM and attentional abilities among 37 long-term survivors of malignant brain tumors, ranging in age from 1.7 to 14.8 (Mdn = 6.5) years at diagnosis, who had been treated with cranial radiation therapy with or without chemotherapy 2.6 to 15.3 (Mdn = 5.7) years earlier. On the Conners' Continuous Performance Test, the Overall Index and 7 of the other 10 indices were significantly deficient compared to age- and gender-corrected normative values. After statistically controlling for the effects of age at diagnosis and time elapsed from treatment, 5 of the 8 indices were significantly associated with cerebral white matter volumes and/or specific regional white matter volumes of the prefrontal/frontal lobe and cingulate gyrus. No gender effects were observed. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood. (JINS, 2004, 10, 180–189.)
doi_str_mv 10.1017/S135561770410204X
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Our group has been especially interested in the effects of treatment on normal appearing white matter (NAWM) on MRI and the influence of NAWM volumes on neurocognitive functioning. The present study assessed NAWM and attentional abilities among 37 long-term survivors of malignant brain tumors, ranging in age from 1.7 to 14.8 (Mdn = 6.5) years at diagnosis, who had been treated with cranial radiation therapy with or without chemotherapy 2.6 to 15.3 (Mdn = 5.7) years earlier. On the Conners' Continuous Performance Test, the Overall Index and 7 of the other 10 indices were significantly deficient compared to age- and gender-corrected normative values. After statistically controlling for the effects of age at diagnosis and time elapsed from treatment, 5 of the 8 indices were significantly associated with cerebral white matter volumes and/or specific regional white matter volumes of the prefrontal/frontal lobe and cingulate gyrus. No gender effects were observed. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood. 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subjects Ability
Academic achievement
Adolescent
Attention
Attention - physiology
Attention deficit hyperactivity disorder
Brain - pathology
Brain - physiopathology
Brain cancer
Brain damage
Brain Neoplasms - complications
Brain Neoplasms - pathology
Cancer
Chemotherapy
Child
Child, Preschool
Childhood cancer
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Cognition Disorders - etiology
Disease-Free Survival
Female
Humans
Infant
Information processing
Magnetic Resonance Imaging
Male
Nervous system
Patients
Radiation therapy
Reaction Time
White matter
title Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood
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