Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood
Children surviving treatment for malignant brain tumors commonly have problems maintaining their premorbid levels of intellectual development and academic achievement. Our group has been especially interested in the effects of treatment on normal appearing white matter (NAWM) on MRI and the influenc...
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Veröffentlicht in: | Journal of the International Neuropsychological Society 2004-03, Vol.10 (2), p.180-189 |
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container_title | Journal of the International Neuropsychological Society |
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creator | MULHERN, RAYMOND K. WHITE, HOLLY A. GLASS, JOHN O. KUN, LARRY E. LEIGH, LAURIE THOMPSON, STEPHEN J. REDDICK, WILBURN E. |
description | Children surviving treatment for malignant brain tumors commonly have
problems maintaining their premorbid levels of intellectual development
and academic achievement. Our group has been especially interested in
the effects of treatment on normal appearing white matter (NAWM) on MRI
and the influence of NAWM volumes on neurocognitive functioning. The
present study assessed NAWM and attentional abilities among 37
long-term survivors of malignant brain tumors, ranging in age from 1.7
to 14.8 (Mdn = 6.5) years at diagnosis, who had been treated
with cranial radiation therapy with or without chemotherapy 2.6 to 15.3
(Mdn = 5.7) years earlier. On the Conners' Continuous
Performance Test, the Overall Index and 7 of the other 10 indices were
significantly deficient compared to age- and gender-corrected normative
values. After statistically controlling for the effects of age at
diagnosis and time elapsed from treatment, 5 of the 8 indices were
significantly associated with cerebral white matter volumes and/or
specific regional white matter volumes of the prefrontal/frontal
lobe and cingulate gyrus. No gender effects were observed. The results
of the present study further support the contention that NAWM is an
important substrate for treatment-induced neurocognitive problems among
survivors of malignant brain tumors of childhood. (JINS, 2004,
10, 180–189.) |
doi_str_mv | 10.1017/S135561770410204X |
format | Article |
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problems maintaining their premorbid levels of intellectual development
and academic achievement. Our group has been especially interested in
the effects of treatment on normal appearing white matter (NAWM) on MRI
and the influence of NAWM volumes on neurocognitive functioning. The
present study assessed NAWM and attentional abilities among 37
long-term survivors of malignant brain tumors, ranging in age from 1.7
to 14.8 (Mdn = 6.5) years at diagnosis, who had been treated
with cranial radiation therapy with or without chemotherapy 2.6 to 15.3
(Mdn = 5.7) years earlier. On the Conners' Continuous
Performance Test, the Overall Index and 7 of the other 10 indices were
significantly deficient compared to age- and gender-corrected normative
values. After statistically controlling for the effects of age at
diagnosis and time elapsed from treatment, 5 of the 8 indices were
significantly associated with cerebral white matter volumes and/or
specific regional white matter volumes of the prefrontal/frontal
lobe and cingulate gyrus. No gender effects were observed. The results
of the present study further support the contention that NAWM is an
important substrate for treatment-induced neurocognitive problems among
survivors of malignant brain tumors of childhood. (JINS, 2004,
10, 180–189.)</description><identifier>ISSN: 1355-6177</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S135561770410204X</identifier><identifier>PMID: 15012838</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Ability ; Academic achievement ; Adolescent ; Attention ; Attention - physiology ; Attention deficit hyperactivity disorder ; Brain - pathology ; Brain - physiopathology ; Brain cancer ; Brain damage ; Brain Neoplasms - complications ; Brain Neoplasms - pathology ; Cancer ; Chemotherapy ; Child ; Child, Preschool ; Childhood cancer ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Disease-Free Survival ; Female ; Humans ; Infant ; Information processing ; Magnetic Resonance Imaging ; Male ; Nervous system ; Patients ; Radiation therapy ; Reaction Time ; White matter</subject><ispartof>Journal of the International Neuropsychological Society, 2004-03, Vol.10 (2), p.180-189</ispartof><rights>2004 The International Neuropsychological Society</rights><rights>Copyright Cambridge University Press Mar 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-1339ee7112da08d801c3c0f7b65bd0f0a6470da99f14ee70748486129399ea3a3</citedby><cites>FETCH-LOGICAL-c437t-1339ee7112da08d801c3c0f7b65bd0f0a6470da99f14ee70748486129399ea3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S135561770410204X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15012838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MULHERN, RAYMOND K.</creatorcontrib><creatorcontrib>WHITE, HOLLY A.</creatorcontrib><creatorcontrib>GLASS, JOHN O.</creatorcontrib><creatorcontrib>KUN, LARRY E.</creatorcontrib><creatorcontrib>LEIGH, LAURIE</creatorcontrib><creatorcontrib>THOMPSON, STEPHEN J.</creatorcontrib><creatorcontrib>REDDICK, WILBURN E.</creatorcontrib><title>Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>Children surviving treatment for malignant brain tumors commonly have
problems maintaining their premorbid levels of intellectual development
and academic achievement. Our group has been especially interested in
the effects of treatment on normal appearing white matter (NAWM) on MRI
and the influence of NAWM volumes on neurocognitive functioning. The
present study assessed NAWM and attentional abilities among 37
long-term survivors of malignant brain tumors, ranging in age from 1.7
to 14.8 (Mdn = 6.5) years at diagnosis, who had been treated
with cranial radiation therapy with or without chemotherapy 2.6 to 15.3
(Mdn = 5.7) years earlier. On the Conners' Continuous
Performance Test, the Overall Index and 7 of the other 10 indices were
significantly deficient compared to age- and gender-corrected normative
values. After statistically controlling for the effects of age at
diagnosis and time elapsed from treatment, 5 of the 8 indices were
significantly associated with cerebral white matter volumes and/or
specific regional white matter volumes of the prefrontal/frontal
lobe and cingulate gyrus. No gender effects were observed. The results
of the present study further support the contention that NAWM is an
important substrate for treatment-induced neurocognitive problems among
survivors of malignant brain tumors of childhood. (JINS, 2004,
10, 180–189.)</description><subject>Ability</subject><subject>Academic achievement</subject><subject>Adolescent</subject><subject>Attention</subject><subject>Attention - physiology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain cancer</subject><subject>Brain damage</subject><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood cancer</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Information processing</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Nervous system</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Reaction Time</subject><subject>White matter</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0UFrFTEQB_Agiq3VD-BFggdvq5kkm2yOpbRPpSJiBW8hu8m-l7qb1CRb7bc3j7dYUMRTBv6_GYYMQs-BvAYC8s1nYG0rQErCgVDCvz5Ax8CFaqQQ8LDWNW72-RF6kvM1IcCAkMfoCFoCtGPdMfKnpbhQfAxmwuMShn3pwxabYPGPnS8Oz6aShH0obpt8ucNmjhXkJd3625gyjmM1k98GEwruk_EBl2Vek2HnJ7uL0T5Fj0YzZfdsfU_Ql4vzq7O3zeXHzbuz08tm4EyWBhhTzkkAag3pbEdgYAMZZS_a3pKRGMElsUapEXh1RPKOdwKoYko5www7Qa8Oc29S_L64XPTs8-CmyQQXl6wlSApUiv9CULQDJnmFL_-A13FJ9cOyptApKriAiuCAhhRzTm7UN8nPJt1pIHp_Lf3XtWrPi3Xw0s_O3nes56mgOQCfi_v5OzfpmxaSyVaLzSetNu-vNhdU6A_Vs3UJM_fJ2627X_Xfa_wCQAiuVw</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>MULHERN, RAYMOND K.</creator><creator>WHITE, HOLLY A.</creator><creator>GLASS, JOHN O.</creator><creator>KUN, LARRY E.</creator><creator>LEIGH, LAURIE</creator><creator>THOMPSON, STEPHEN J.</creator><creator>REDDICK, WILBURN E.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20040301</creationdate><title>Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood</title><author>MULHERN, RAYMOND K. ; WHITE, HOLLY A. ; GLASS, JOHN O. ; KUN, LARRY E. ; LEIGH, LAURIE ; THOMPSON, STEPHEN J. ; REDDICK, WILBURN E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-1339ee7112da08d801c3c0f7b65bd0f0a6470da99f14ee70748486129399ea3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Ability</topic><topic>Academic achievement</topic><topic>Adolescent</topic><topic>Attention</topic><topic>Attention - physiology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain cancer</topic><topic>Brain damage</topic><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - pathology</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood cancer</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Information processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Nervous system</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Reaction Time</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MULHERN, RAYMOND K.</creatorcontrib><creatorcontrib>WHITE, HOLLY A.</creatorcontrib><creatorcontrib>GLASS, JOHN O.</creatorcontrib><creatorcontrib>KUN, LARRY E.</creatorcontrib><creatorcontrib>LEIGH, LAURIE</creatorcontrib><creatorcontrib>THOMPSON, STEPHEN J.</creatorcontrib><creatorcontrib>REDDICK, WILBURN E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of the International Neuropsychological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MULHERN, RAYMOND K.</au><au>WHITE, HOLLY A.</au><au>GLASS, JOHN O.</au><au>KUN, LARRY E.</au><au>LEIGH, LAURIE</au><au>THOMPSON, STEPHEN J.</au><au>REDDICK, WILBURN E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood</atitle><jtitle>Journal of the International Neuropsychological Society</jtitle><addtitle>J Int Neuropsychol Soc</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>10</volume><issue>2</issue><spage>180</spage><epage>189</epage><pages>180-189</pages><issn>1355-6177</issn><eissn>1469-7661</eissn><abstract>Children surviving treatment for malignant brain tumors commonly have
problems maintaining their premorbid levels of intellectual development
and academic achievement. Our group has been especially interested in
the effects of treatment on normal appearing white matter (NAWM) on MRI
and the influence of NAWM volumes on neurocognitive functioning. The
present study assessed NAWM and attentional abilities among 37
long-term survivors of malignant brain tumors, ranging in age from 1.7
to 14.8 (Mdn = 6.5) years at diagnosis, who had been treated
with cranial radiation therapy with or without chemotherapy 2.6 to 15.3
(Mdn = 5.7) years earlier. On the Conners' Continuous
Performance Test, the Overall Index and 7 of the other 10 indices were
significantly deficient compared to age- and gender-corrected normative
values. After statistically controlling for the effects of age at
diagnosis and time elapsed from treatment, 5 of the 8 indices were
significantly associated with cerebral white matter volumes and/or
specific regional white matter volumes of the prefrontal/frontal
lobe and cingulate gyrus. No gender effects were observed. The results
of the present study further support the contention that NAWM is an
important substrate for treatment-induced neurocognitive problems among
survivors of malignant brain tumors of childhood. (JINS, 2004,
10, 180–189.)</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><pmid>15012838</pmid><doi>10.1017/S135561770410204X</doi><tpages>10</tpages></addata></record> |
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source | MEDLINE; Cambridge University Press Journals Complete |
subjects | Ability Academic achievement Adolescent Attention Attention - physiology Attention deficit hyperactivity disorder Brain - pathology Brain - physiopathology Brain cancer Brain damage Brain Neoplasms - complications Brain Neoplasms - pathology Cancer Chemotherapy Child Child, Preschool Childhood cancer Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - etiology Disease-Free Survival Female Humans Infant Information processing Magnetic Resonance Imaging Male Nervous system Patients Radiation therapy Reaction Time White matter |
title | Attentional functioning and white matter integrity among survivors of malignant brain tumors of childhood |
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