Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice

HMG-CoA reductase inhibitors (statins) are cholesterol-lowering drugs and reduce the risk of myocardial infarction and stroke. In this study we investigated whether rosuvastatin, a new, potent HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide (NO) expression and activity and protects...

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Veröffentlicht in:	Brain research 2002-06, Vol.942 (1), p.23-30
Hauptverfasser:	Laufs, Ulrich, Gertz, Karen, Dirnagl, Ulrich, Böhm, Michael, Nickenig, Georg, Endres, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Ischemia - drug therapy Brain Ischemia - enzymology Brain Ischemia - physiopathology Cells, Cultured Cerebral Infarction - drug therapy Cerebral Infarction - enzymology Cerebral Infarction - physiopathology Cerebral ischemia Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Dose-Response Relationship, Drug Endothelial nitric oxide synthase Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - physiopathology Fluorobenzenes - pharmacology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - physiology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - enzymology Infarction, Middle Cerebral Artery - physiopathology Lipid metabolism Medical sciences Mice Mice, Inbred Strains Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Pharmacology. Drug treatments Pyrimidines Reperfusion Injury - drug therapy Reperfusion Injury - enzymology Reperfusion Injury - physiopathology RNA, Messenger - drug effects RNA, Messenger - metabolism Rosuvastatin Calcium Stroke Stroke - drug therapy Stroke - enzymology Stroke - physiopathology Sulfonamides Up-Regulation - drug effects Up-Regulation - physiology
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