Identification of single nucleotide variations in the coding and regulatory regions of the myelin-associated glycoprotein gene and study of their association with multiple sclerosis

The myelin-associated glycoprotein (MAG) gene is an appealing candidate in the 19q13 Multiple Sclerosis (MS) candidate region. Using denaturing high performance liquid chromatography (DHPLC), we identified 14 single nucleotide polymorphisms (SNPs) in MAG coding and regulatory regions, and we tested...

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Veröffentlicht in:	Journal of neuroimmunology 2002-05, Vol.126 (1), p.196-204
Hauptverfasser:	D'Alfonso, Sandra, Mellai, Marta, Giordano, Mara, Pastore, Alessandro, Malferrari, Giulia, Naldi, Paola, Repice, Anna, Liguori, Maria, Cannoni, Stefania, Milanese, Clara, Caputo, Domenico, Savettieri, Giovanni, Momigliano-Richiardi, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Adult Chromatography, High Pressure Liquid Chromosomes, Human, Pair 19 DNA pools Female Gene Frequency Genetic association Heterozygote Humans MAG Male Middle Aged Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Myelin-Associated Glycoprotein - analysis Myelin-Associated Glycoprotein - genetics Myelin-Associated Glycoprotein - immunology Polymorphism, Single Nucleotide - immunology SNP
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Zusammenfassung:	The myelin-associated glycoprotein (MAG) gene is an appealing candidate in the 19q13 Multiple Sclerosis (MS) candidate region. Using denaturing high performance liquid chromatography (DHPLC), we identified 14 single nucleotide polymorphisms (SNPs) in MAG coding and regulatory regions, and we tested their possible association with MS in Italian patient and control DNA pools. Eight variations had a frequency
ISSN:	0165-5728 1872-8421
DOI:	10.1016/S0165-5728(02)00061-9